PMID- 25206479
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140910
LR  - 20211021
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 8
IP  - 2
DP  - 2013 Jan 15
TI  - Adenosine triphosphate promotes locomotor recovery after spinal cord injury by 
      activating mammalian target of rapamycin pathway in rats.
PG  - 101-10
LID - 10.3969/j.issn.1673-5374.2013.02.001 [doi]
AB  - The mammalian target of rapamycin (mTOR) pathway plays an important role in 
      neuronal growth, proliferation and differentiation. To better understand the role 
      of mTOR pathway involved in the induction of spinal cord injury, rat models of 
      spinal cord injury were established by modified Allen's stall method and 
      interfered for 7 days by intraperitoneal administration of mTOR activator 
      adenosine triphosphate and mTOR kinase inhibitor rapamycin. At 1-4 weeks after 
      spinal cord injury induction, the Basso, Beattie and Bresnahan locomotor rating 
      scale was used to evaluate rat locomotor function, and immunohistochemical 
      staining and western blot analysis were used to detect the expression of nestin 
      (neural stem cell marker), neuronal nuclei (neuronal marker), neuron specific 
      enolase, neurofilament protein 200 (axonal marker), glial fibrillary acidic 
      protein (astrocyte marker), Akt, mTOR and signal transduction and activator of 
      transcription 3 (STAT3). Results showed th+at adenosine triphosphate-mediated 
      Akt/mTOR/STAT3 pathway increased endogenous neural stem cells, induced 
      neurogenesis and axonal growth, inhibited excessive astrogliosis and improved the 
      locomotor function of rats with spinal cord injury.
FAU - Sun, Zhengang
AU  - Sun Z
AD  - Department of Spine Surgery, First People's Hospital of Qingdao Economic & 
      Technological Development Area, Qingdao 266555, Shandong Province, China ; Second 
      Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, 
      China.
FAU - Hu, Lingyun
AU  - Hu L
AD  - Second Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu 
      Province, China ; Department of Orthopedics, Nanchong Central Hospital, Nanchong 
      637000, Sichuan Province, China.
FAU - Wen, Yimin
AU  - Wen Y
AD  - Second Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu 
      Province, China ; Department of Spine Surgery, Lanzhou General Hospital of 
      Lanzhou Military Region, Lanzhou 730050, Gansu Province, China.
FAU - Chen, Keming
AU  - Chen K
AD  - Department of Spine Surgery, Lanzhou General Hospital of Lanzhou Military Region, 
      Lanzhou 730050, Gansu Province, China.
FAU - Sun, Zhenjuan
AU  - Sun Z
AD  - Department of Information, Qingdao Eighth People's Hospital, Qingdao 266100, 
      Shandong Province, China.
FAU - Yue, Haiyuan
AU  - Yue H
AD  - Second Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu 
      Province, China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Second Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu 
      Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC4107506
OTO - NOTNLM
OT  - adenosine triphosphate
OT  - mammalian target of rapamycin pathway
OT  - neural regeneration
OT  - neuroregeneration
OT  - photographs-containing paper
OT  - rapamycin
OT  - serine/threonine-specific protein kinase
OT  - signal pathway
OT  - signal transduction and activator of transcription 3
OT  - spinal cord injury
COIS- Conflicts of interest: None declared.
EDAT- 2013/01/15 00:00
MHDA- 2013/01/15 00:01
PMCR- 2013/01/15
CRDT- 2014/09/11 06:00
PHST- 2012/07/20 00:00 [received]
PHST- 2012/11/10 00:00 [accepted]
PHST- 2014/09/11 06:00 [entrez]
PHST- 2013/01/15 00:00 [pubmed]
PHST- 2013/01/15 00:01 [medline]
PHST- 2013/01/15 00:00 [pmc-release]
AID - NRR-8-101 [pii]
AID - 10.3969/j.issn.1673-5374.2013.02.001 [doi]
PST - ppublish
SO  - Neural Regen Res. 2013 Jan 15;8(2):101-10. doi: 
      10.3969/j.issn.1673-5374.2013.02.001.