PMID- 25207374
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20201113
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 810
DP  - 2014
TI  - Interaction of hedgehog and vitamin D signaling pathways in basal cell 
      carcinomas.
PG  - 329-41
AB  - Basal Cell Carcinomas (BCCs) are the most commonly diagnosed tumors among people 
      in the western world. Most BCCs are caused by mutational inactivation of the 
      tumor suppressor Patched (PTCH), which results in activation of Smoothened (SMO) 
      and of the Hedgehog (HH) signaling pathway. Recent studies indicate that BCC 
      progression involves a crosstalk between Hh signaling, vitamin D derivatives and 
      the vitamin D receptor (Vdr) signaling pathway. This has been demonstrated in 
      BCC-bearing Ptch mutant mice and BCC cell lines, in which both vitamin D3 and its 
      active metabolite calcitriol (1alpha-25(OH)2D3) exert antitumor effects. 
      Interestingly, the antitumor effects are mainly ascribed to an inhibition of Hh 
      signaling. Furthermore, as evident from studies in Vdr deficient mice, calcitriol 
      may also repress the activity of Hh signaling in a Vdr-dependent fashion thereby 
      establishing an additional inhibitory feedback on Hh signaling activity. In this 
      chapter, we discuss the current understanding and controversial findings of the 
      inhibition of Hh signaling by vitamin D derivatives and the implication of these 
      findings for BCC carcinogenesis.
FAU - Albert, Benedikt
AU  - Albert B
FAU - Hahn, Heidi
AU  - Hahn H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Hedgehog Proteins)
RN  - 0 (PTCH1 protein, human)
RN  - 0 (Patched Receptors)
RN  - 0 (Patched-1 Receptor)
RN  - 0 (Ptch1 protein, mouse)
RN  - 0 (Receptors, Calcitriol)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (SMO protein, human)
RN  - 0 (Smoothened Receptor)
RN  - 1406-16-2 (Vitamin D)
RN  - 66772-14-3 (1,25-dihydroxyvitamin D)
SB  - IM
MH  - Animals
MH  - Carcinoma, Basal Cell/genetics/*metabolism/pathology
MH  - Gene Expression Regulation, Neoplastic
MH  - Hedgehog Proteins/genetics/*metabolism
MH  - Humans
MH  - Mice
MH  - Mutation
MH  - Patched Receptors
MH  - Patched-1 Receptor
MH  - Receptors, Calcitriol/genetics/*metabolism
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Receptors, G-Protein-Coupled/genetics/metabolism
MH  - *Signal Transduction
MH  - Skin/metabolism/pathology
MH  - Skin Neoplasms/genetics/*metabolism/pathology
MH  - Smoothened Receptor
MH  - Ultraviolet Rays
MH  - Vitamin D/*analogs & derivatives/*metabolism
EDAT- 2014/09/11 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/09/11 06:00
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - 10.1007/978-1-4939-0437-2_18 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2014;810:329-41. doi: 10.1007/978-1-4939-0437-2_18.