PMID- 25207437
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20211021
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Print)
IS  - 1471-0072 (Linking)
VI  - 15
IP  - 10
DP  - 2014 Oct
TI  - Capping protein regulators fine-tune actin assembly dynamics.
PG  - 677-89
LID - 10.1038/nrm3869 [doi]
AB  - Capping protein (CP) binds the fast growing barbed end of the actin filament and 
      regulates actin assembly by blocking the addition and loss of actin subunits. 
      Recent studies provide new insights into how CP and barbed-end capping are 
      regulated. Filament elongation factors, such as formins and ENA/VASP 
      (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by 
      competing with CP for binding to the barbed end, whereas other molecules, 
      including V-1 and phospholipids, directly bind to CP and sterically block its 
      interaction with the filament. In addition, a diverse and unrelated group of 
      proteins interact with CP through a conserved 'capping protein interaction' (CPI) 
      motif. These proteins, including CARMIL (capping protein, ARP2/3 and myosin I 
      linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) 
      complex subunit FAM21, recruit CP to specific subcellular locations and modulate 
      its actin-capping activity via allosteric effects.
FAU - Edwards, Marc
AU  - Edwards M
AD  - Department of Cell Biology and Physiology, Washington University, St. Louis, 
      Missouri 63110, USA.
FAU - Zwolak, Adam
AU  - Zwolak A
AD  - Department of Physiology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
FAU - Schafer, Dorothy A
AU  - Schafer DA
AD  - Departments of Biology and Cell Biology, University of Virginia, Charlottesville, 
      Virginia 22904, USA.
FAU - Sept, David
AU  - Sept D
AD  - Department of Biomedical Engineering and Center for Computational Medicine and 
      Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
FAU - Dominguez, Roberto
AU  - Dominguez R
AD  - Department of Physiology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
FAU - Cooper, John A
AU  - Cooper JA
AD  - Department of Cell Biology and Physiology, Washington University, St. Louis, 
      Missouri 63110, USA.
LA  - eng
GR  - R01 GM038542/GM/NIGMS NIH HHS/United States
GR  - MH087950/MH/NIMH NIH HHS/United States
GR  - GM038542/GM/NIGMS NIH HHS/United States
GR  - 5T90DA02287104/DA/NIDA NIH HHS/United States
GR  - R01 MH087950/MH/NIMH NIH HHS/United States
GR  - GM073791/GM/NIGMS NIH HHS/United States
GR  - R01 GM095509/GM/NIGMS NIH HHS/United States
GR  - GM095509/GM/NIGMS NIH HHS/United States
GR  - R01 GM073791/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20140910
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Actin Capping Proteins)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (CARMIL1 protein, human)
RN  - 0 (CD2-associated protein)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (ENA-VASP proteins)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Phosphatidylinositol Phosphates)
RN  - 0 (WASH protein, human)
SB  - IM
EIN - Nat Rev Mol Cell Biol. 2014 Nov;15(11):701
MH  - Actin Capping Proteins/*metabolism/physiology
MH  - Actin Cytoskeleton/*physiology
MH  - Adaptor Proteins, Signal Transducing/metabolism/physiology
MH  - Amino Acid Sequence
MH  - Carrier Proteins/metabolism/physiology
MH  - Cytoskeletal Proteins/metabolism/physiology
MH  - DNA-Binding Proteins/*metabolism/physiology
MH  - Humans
MH  - Microfilament Proteins/metabolism/physiology
MH  - Models, Molecular
MH  - Phosphatidylinositol Phosphates/chemistry
MH  - Protein Binding
MH  - Protein Conformation
PMC - PMC4271544
MID - NIHMS647391
EDAT- 2014/09/11 06:00
MHDA- 2014/11/19 06:00
PMCR- 2014/12/19
CRDT- 2014/09/11 06:00
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
PHST- 2014/12/19 00:00 [pmc-release]
AID - nrm3869 [pii]
AID - 10.1038/nrm3869 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2014 Oct;15(10):677-89. doi: 10.1038/nrm3869. Epub 2014 
      Sep 10.