PMID- 25207821
OWN - NLM
STAT- MEDLINE
DCOM- 20150311
LR  - 20211021
IS  - 1093-5266 (Print)
IS  - 1615-5742 (Electronic)
IS  - 1093-5266 (Linking)
VI  - 17
IP  - 6
DP  - 2014 Nov-Dec
TI  - Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a 
      report from the Children's Oncology Group.
PG  - 441-9
LID - 10.2350/14-06-1505-OA.1 [doi]
AB  - Prognostic effects of Mitosis-Karyorrhexis Index (MKI) used in the International 
      Neuroblastoma Pathology Classification (INPC) are age-dependent. A total of 4,282 
      neuroblastomas reviewed at the Children's Oncology Group Neuroblastoma Pathology 
      Reference Laboratory (8/1/2001-3/31/2012) included 2,365 low-MKI (L-MKI), 1,068 
      intermediate-MKI (I-MKI), and 849 high-MKI (H-MKI) tumors. Cox proportional 
      hazards models were fit to determine age cut-offs at which the relative risk of 
      event/death was maximized in each MKI class. Backward-selected Cox models were 
      fit to determine the prognostic strength of the age cut-offs for survival in the 
      presence of other prognostic factors. The age cut-offs used in the INPC for L-MKI 
      tumors (<60 months, n  =  2,710, 84.0% +/- 1.0% event-free survival [EFS], 93.8 +/- 
      0.7% overall survival [OS] vs >/=60 months, n  =  195, 49.8% +/- 4.6% EFS, 71.7% +/- 
      4.1% OS; P < 0.0001) and I-MKI tumors (<18 months, n  =  568, 83.8% +/- 2% EFS, 
      93.7% +/- 1.3% OS vs >/=18 months, n  =  500, 51.4% +/- 2.9% EFS, 66.7% +/- 2.7% OS; P < 
      0.0001) were within the effective range for distinguishing prognostic groups. As 
      for H-MKI tumors (no cut-off age in the INPC, 51.0% +/- 2.2% EFS, 64.4% +/- 2.1% OS), 
      a new cut-off of 3-4 months was suggested (<4 months, n  =  38, 82.3% +/- 8.4% EFS, 
      81.8% +/- 8.5% OS vs >/=4 months, n  =  811, 49.6% +/- 2.2% EFS, 63.7% +/- 2.1% OS, P  =  
      0.0034 and 0.0437, respectively). Multivariate analyses revealed that cut-offs of 
      60 and 18 months for L-MKI and I-MKI tumors, respectively, were independently 
      prognostic. However, the cut-off of 4 months for H-MKI tumors did not reach 
      statistical significance in the presence of other factors. The age cut-offs for 
      MKI classes (60 months for L-MKI, 18 months for I-MKI, no cut-off for H-MKI) in 
      the current INPC are reasonable and effective for distinguishing prognostic 
      groups with increased risk of event/death for older patients.
FAU - Teshiba, Risa
AU  - Teshiba R
AD  - 1 Department of Pathology & Laboratory Medicine, Children's Hospital Los Angeles, 
      and University of Southern California Keck School of Medicine, 4650 Sunset 
      Boulevard, MS #43, Los Angeles, CA 90027, USA.
FAU - Kawano, Shinya
AU  - Kawano S
FAU - Wang, Larry L
AU  - Wang LL
FAU - He, Lejian
AU  - He L
FAU - Naranjo, Arlene
AU  - Naranjo A
FAU - London, Wendy B
AU  - London WB
FAU - Seeger, Robert C
AU  - Seeger RC
FAU - Gastier-Foster, Julie M
AU  - Gastier-Foster JM
FAU - Look, A Thomas
AU  - Look AT
FAU - Hogarty, Michael D
AU  - Hogarty MD
FAU - Cohn, Susan L
AU  - Cohn SL
FAU - Maris, John M
AU  - Maris JM
FAU - Park, Julie R
AU  - Park JR
FAU - Shimada, Hiroyuki
AU  - Shimada H
LA  - eng
GR  - U10 CA098413/CA/NCI NIH HHS/United States
GR  - U10 CA098543/CA/NCI NIH HHS/United States
GR  - U10 CA180886/CA/NCI NIH HHS/United States
GR  - U10 CA180899/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140910
PL  - United States
TA  - Pediatr Dev Pathol
JT  - Pediatric and developmental pathology : the official journal of the Society for 
      Pediatric Pathology and the Paediatric Pathology Society
JID - 9809673
RN  - 0 (MYCN protein, human)
RN  - 0 (N-Myc Proto-Oncogene Protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Oncogene Proteins)
SB  - IM
MH  - Age Factors
MH  - Biopsy
MH  - Chi-Square Distribution
MH  - Child, Preschool
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Gene Amplification
MH  - Humans
MH  - Infant
MH  - Kaplan-Meier Estimate
MH  - *Karyotyping
MH  - *Mitosis
MH  - *Mitotic Index
MH  - Multivariate Analysis
MH  - N-Myc Proto-Oncogene Protein
MH  - Neoplasm Staging
MH  - Neuroblastoma/*diagnosis/genetics/mortality/pathology
MH  - Nuclear Proteins/genetics
MH  - Oncogene Proteins/genetics
MH  - Peripheral Nervous System Neoplasms/*diagnosis/genetics/mortality/pathology
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Time Factors
PMC - PMC4340697
MID - NIHMS658351
OTO - NOTNLM
OT  - International Neuroblastoma Pathology Classification
OT  - age cut-off
OT  - mitosis-karyorrhexis index
OT  - neuroblastoma
OT  - prognosis
EDAT- 2014/09/11 06:00
MHDA- 2015/03/12 06:00
PMCR- 2015/02/25
CRDT- 2014/09/11 06:00
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2015/03/12 06:00 [medline]
PHST- 2015/02/25 00:00 [pmc-release]
AID - 10.2350/14-06-1505-OA.1 [doi]
PST - ppublish
SO  - Pediatr Dev Pathol. 2014 Nov-Dec;17(6):441-9. doi: 10.2350/14-06-1505-OA.1. Epub 
      2014 Sep 10.