PMID- 25207957
OWN - NLM
STAT- MEDLINE
DCOM- 20160324
LR  - 20150514
IS  - 1532-4206 (Electronic)
IS  - 0743-5800 (Linking)
VI  - 40
IP  - 2
DP  - 2015
TI  - Visfatin and oxidative stress influence endothelial progenitor cells in obese 
      populations.
PG  - 83-7
LID - 10.3109/07435800.2014.952016 [doi]
AB  - PURPOSE/AIMS OF THE STUDY: This study sought to study the levels of circulating 
      endothelial progenitor cells (EPCs), serum visfatin, and oxidative stress in 
      obese individuals, and their respective correlations. MATERIALS AND METHODS: The 
      circulating levels of EPCs were measured through detecting CD309 and CD34 by flow 
      cytometry. Serum visfatin concentration was measured by enzyme-linked 
      immunosorbent assay in 31 obese men [obese group: BMI 28.9 +/- 0.86 kg/m(2); age 
      44.93 +/- 1.78 years (range 40 to 47)] and 30 normal-weight men [control group: BMI 
      22.7 +/- 1.22 kg/m(2); age 44.03 +/- 1.87 years (range 41 to 47)]. Indexes of 
      oxidative stress were assayed by a colorimetric method. The relationships between 
      circulating EPCs, serum visfatin, and oxidative stress markers were further 
      analyzed by multiple linear regression analysis. Statistical significance was set 
      at p < 0.05. RESULTS: The obese group showed higher levels of serum visfatin and 
      a lower level of circulating EPCs compared with controls. Serum superoxide 
      dismutase (SOD) activity, total antioxidant capacity (T-AOC), and glutathione 
      peroxidase (GSH-px) activity were significantly lower in obese subjects than in 
      controls, while levels of serum malondialdehyde (MDA) were significantly higher. 
      Circulating EPCs were positively associated with SOD (beta = 0.306) and LnHOMA-IR (beta 
      = 0.223) and negatively associated with BMI (beta = -0.321), serum visfatin (beta 
      = -0.236), and MDA (beta = -0.293). CONCLUSIONS: The quantity of circulating EPCs 
      decreases in obese individuals, along with increased serum visfatin and oxidative 
      stress product. Visfatin and oxidative stress might therefore impact on the 
      circulating EPCs in obese populations.
FAU - Chen, Shuchun
AU  - Chen S
AD  - Hebei Research Institute for Endocrine and Metabolic Diseases , Shijiazhuang, 
      Hebei , P.R. China .
FAU - Sun, Lina
AU  - Sun L
FAU - Gao, Haina
AU  - Gao H
FAU - Ren, Luping
AU  - Ren L
FAU - Liu, Na
AU  - Liu N
FAU - Song, Guangyao
AU  - Song G
LA  - eng
PT  - Journal Article
DEP - 20140910
PL  - England
TA  - Endocr Res
JT  - Endocrine research
JID - 8408548
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
SB  - IM
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cytokines/*blood
MH  - Endothelial Progenitor Cells/*pathology/*physiology
MH  - Humans
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Nicotinamide Phosphoribosyltransferase/*blood
MH  - Obesity/*blood/*pathology
MH  - Oxidative Stress/*physiology
MH  - Superoxide Dismutase/blood
OTO - NOTNLM
OT  - Endothelial progenitor cells
OT  - obesity
OT  - oxidative stress
OT  - visfatin
EDAT- 2014/09/11 06:00
MHDA- 2016/03/25 06:00
CRDT- 2014/09/11 06:00
PHST- 2014/09/11 06:00 [entrez]
PHST- 2014/09/11 06:00 [pubmed]
PHST- 2016/03/25 06:00 [medline]
AID - 10.3109/07435800.2014.952016 [doi]
PST - ppublish
SO  - Endocr Res. 2015;40(2):83-7. doi: 10.3109/07435800.2014.952016. Epub 2014 Sep 10.