PMID- 25208949
OWN - NLM
STAT- MEDLINE
DCOM- 20150616
LR  - 20151119
IS  - 1365-2982 (Electronic)
IS  - 1350-1925 (Linking)
VI  - 26
IP  - 11
DP  - 2014 Nov
TI  - Correlation between oropharyngeal pH-monitoring and esophageal pH-impedance 
      monitoring in patients with suspected GERD-related extra-esophageal symptoms.
PG  - 1557-64
LID - 10.1111/nmo.12422 [doi]
AB  - BACKGROUND: 24-hour esophageal pH-impedance (pH-MII) is not totally reliable for 
      laryngopharyngeal reflux (LPR). Oropharyngeal (OP) pH-monitoring with the Dx-pH 
      probe may detect LPR better. The correlation between these two techniques is not 
      thoroughly established. Aim of this study is to examine the correlation between 
      OP pH-metry and esophageal pH-MII monitoring. METHODS: Thirty-six consecutive 
      patients with suspected gastroesophageal reflux disease-related extra-esophageal 
      symptoms were evaluated using 24-h OP-pH and concomitant esophageal pH-MII 
      monitoring. OP events were defined as: drop in pH below thresholds of 5.5, 5.0, 
      4.5, 4.0 or drop in pH of at least 10% from a running baseline. Temporal 
      relationship between OP and esophageal reflux events and outcomes of the two 
      tests were evaluated. KEY RESULTS: 2394 refluxes were detected by pH-MII; of 
      these only 120 were detected also by OP Dx-probe. On the other hand, the 
      proportion of OP-pH events which were temporally related to an episode of distal 
      reflux ranged from 0% to 17%, depending on the proximal pH criteria used. In 8/36 
      patients both tests were pathological, while in 10/36 they were both normal; 
      14/36 patients had pathological OP reflux, but a normal pH-MII test; 4/36 
      patients had pathological pH-MII, but a normal OP reflux. CONCLUSIONS & 
      INFERENCES: The correlation between OP pH-metry and pH-MII was weak. At present, 
      the absence of a reliable gold standard for the diagnosis of LPR and the 
      uncertain etiology of the pharyngeal pH alterations make it difficult to decide 
      which is the most reliable technique for the diagnosis of true LPR.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Mazzoleni, G
AU  - Mazzoleni G
AD  - Division of Gastroenterology and Gastrointestinal Endoscopy, Vita-Salute San 
      Raffaele University, San Raffaele Scientific Institute, Milan, Italy.
FAU - Vailati, C
AU  - Vailati C
FAU - Lisma, D G
AU  - Lisma DG
FAU - Testoni, P A
AU  - Testoni PA
FAU - Passaretti, S
AU  - Passaretti S
LA  - eng
PT  - Journal Article
DEP - 20140910
PL  - England
TA  - Neurogastroenterol Motil
JT  - Neurogastroenterology and motility
JID - 9432572
SB  - IM
MH  - Electric Impedance
MH  - *Esophageal pH Monitoring
MH  - Female
MH  - Gastroesophageal Reflux/complications
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Laryngopharyngeal Reflux/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Oropharynx/*chemistry
OTO - NOTNLM
OT  - Dx-pH probe
OT  - laryngopharyngeal reflux
OT  - pH-impedance monitoring
EDAT- 2014/09/12 06:00
MHDA- 2015/06/17 06:00
CRDT- 2014/09/12 06:00
PHST- 2014/03/17 00:00 [received]
PHST- 2014/08/06 00:00 [accepted]
PHST- 2014/09/12 06:00 [entrez]
PHST- 2014/09/12 06:00 [pubmed]
PHST- 2015/06/17 06:00 [medline]
AID - 10.1111/nmo.12422 [doi]
PST - ppublish
SO  - Neurogastroenterol Motil. 2014 Nov;26(11):1557-64. doi: 10.1111/nmo.12422. Epub 
      2014 Sep 10.