PMID- 25209292
OWN - NLM
STAT- MEDLINE
DCOM- 20150107
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 34
IP  - 37
DP  - 2014 Sep 10
TI  - A positive autoregulatory BDNF feedback loop via C/EBPbeta mediates hippocampal 
      memory consolidation.
PG  - 12547-59
LID - 10.1523/JNEUROSCI.0324-14.2014 [doi]
AB  - Little is known about the temporal progression and regulation of the mechanisms 
      underlying memory consolidation. Brain-derived-neurotrophic-factor (BDNF) has 
      been shown to mediate the maintenance of memory consolidation, but the mechanisms 
      of this regulation remain unclear. Using inhibitory avoidance (IA) in rats, here 
      we show that a hippocampal BDNF-positive autoregulatory feedback loop via 
      CCAAT-enhancer binding protein beta (C/EBPbeta) is necessary to mediate memory 
      consolidation. At training, a very rapid, learning-induced requirement of BDNF 
      accompanied by rapid de novo translation controls the induction of a persistent 
      activation of cAMP-response element binding-protein (CREB) and C/EBPbeta expression. 
      The latter, in turn, controls an increase in expression of bdnf exon IV 
      transcripts and BDNF protein, both of which are necessary and, together with the 
      initial BDNF requirement, mediate memory consolidation. The autoregulatory loop 
      terminates by 48 h after training with decreased C/EBPbeta and pCREB and increased 
      methyl-CpG binding protein-2, histone-deacetylase-2, and switch-independent-3a 
      binding at the bdnf exon IV promoter.
CI  - Copyright (c) 2014 the authors 0270-6474/14/3412547-13$15.00/0.
FAU - Bambah-Mukku, Dhananjay
AU  - Bambah-Mukku D
AUID- ORCID: 0000-0001-5822-6326
AD  - Center for Neural Science, New York University, New York, New York 10003 and 
      Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine 
      at Mount Sinai, New York, New York 10029.
FAU - Travaglia, Alessio
AU  - Travaglia A
AD  - Center for Neural Science, New York University, New York, New York 10003 and.
FAU - Chen, Dillon Y
AU  - Chen DY
AD  - Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine 
      at Mount Sinai, New York, New York 10029.
FAU - Pollonini, Gabriella
AU  - Pollonini G
AD  - Center for Neural Science, New York University, New York, New York 10003 and.
FAU - Alberini, Cristina M
AU  - Alberini CM
AD  - Center for Neural Science, New York University, New York, New York 10003 and 
      ca60@nyu.edu.
LA  - eng
GR  - R01 MH065635/MH/NIMH NIH HHS/United States
GR  - R37 MH065635/MH/NIMH NIH HHS/United States
GR  - R37-MH065635/MH/NIMH NIH HHS/United States
GR  - R01-MH065635/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (CCAAT-Enhancer-Binding Protein-beta)
RN  - 0 (Cebpb protein, rat)
SB  - IM
MH  - Animals
MH  - Avoidance Learning/*physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CCAAT-Enhancer-Binding Protein-beta/*metabolism
MH  - Feedback, Physiological/physiology
MH  - Hippocampus/*physiology
MH  - *Inhibition, Psychological
MH  - Male
MH  - Memory, Long-Term/*physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Signal Transduction/physiology
PMC - PMC4160783
OTO - NOTNLM
OT  - BDNF
OT  - C/EBP
OT  - consolidation
OT  - hippocampus
OT  - memory
OT  - memory persistence
EDAT- 2014/09/12 06:00
MHDA- 2015/01/08 06:00
PMCR- 2015/03/10
CRDT- 2014/09/12 06:00
PHST- 2014/09/12 06:00 [entrez]
PHST- 2014/09/12 06:00 [pubmed]
PHST- 2015/01/08 06:00 [medline]
PHST- 2015/03/10 00:00 [pmc-release]
AID - 34/37/12547 [pii]
AID - 0324-14 [pii]
AID - 10.1523/JNEUROSCI.0324-14.2014 [doi]
PST - ppublish
SO  - J Neurosci. 2014 Sep 10;34(37):12547-59. doi: 10.1523/JNEUROSCI.0324-14.2014.