PMID- 25209410
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20211021
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 26
IP  - 2
DP  - 2015 Feb
TI  - Bone mineral density after childhood cancer in 346 long-term adult survivors of 
      childhood cancer.
PG  - 521-9
LID - 10.1007/s00198-014-2878-z [doi]
AB  - SUMMARY: More than 45 % of long-term childhood cancer survivors (CCS) were 
      diagnosed with osteopenia. Our data suggest that greater awareness for osteopenia 
      is warranted in long-term CCS, especially in survivors who are older than 30 
      years, male, and underweight and were treated with cranial-spinal radiotherapy 
      and/or steroids. INTRODUCTION: Osteopenia is a potential complication of 
      childhood cancer treatment, but the magnitude of this problem in survivors is 
      unknown. We examined (determinants of) bone mineral density (BMD) status in 
      long-term survivors of adult childhood cancer. METHODS: This retrospective 
      single-centre cohort study included 346 subjects with the most common types of 
      childhood cancer. Subjects had a median age at diagnosis of 7.0 years (range 
      0.1-16.8 years), a median age at follow-up of 24.5 years (range 18.0-47.6 years) 
      and a median follow-up time of 16.7 years (range 5.6-39.9 years). Total body BMD 
      (BMDTB) and BMD of the lumbar spine (BMDLS) were measured by dual X-ray 
      absorptiometry. Osteopenia was defined as BMD standardized deviation score (SDS) 
      below -1. RESULTS: Survivors had a lower BMDTB and BMDLS (mean SDS -0.55; p<0.001 
      and -0.30; p<0.001, respectively) as compared to healthy peers. Osteopenia (BMDTB 
      and/or BMDLS) was present in 45% of the survivors. Multivariate logistic 
      regression analyses identified age at diagnosis<12 years, age>30 years at 
      follow-up, male gender, underweight at follow-up and treatment with 
      cranial-spinal radiotherapy or prednisone as independent prognostic factors for 
      osteopenia. CONCLUSIONS: This large cohort of childhood cancer survivors 
      identified osteopenia in 45% of CCS. This indicates that greater awareness is 
      warranted, especially in survivors who are older than 30 years, male, have 
      underweight and were treated with cranial-spinal radiotherapy and/or steroids.
FAU - den Hoed, M A H
AU  - den Hoed MA
AD  - Department of Paediatric Oncology/Haematology, Erasmus University Medical Center 
      (Erasmus MC)-Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ, 
      Rotterdam, The Netherlands.
FAU - Klap, B C
AU  - Klap BC
FAU - te Winkel, M L
AU  - te Winkel ML
FAU - Pieters, R
AU  - Pieters R
FAU - van Waas, M
AU  - van Waas M
FAU - Neggers, S J C M M
AU  - Neggers SJ
FAU - Boot, A M
AU  - Boot AM
FAU - Blijdorp, K
AU  - Blijdorp K
FAU - van Dorp, W
AU  - van Dorp W
FAU - Pluijm, S M F
AU  - Pluijm SM
FAU - van den Heuvel-Eibrink, M M
AU  - van den Heuvel-Eibrink MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140911
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Adult
MH  - Bone Density/physiology
MH  - Bone Diseases, Metabolic/complications/*diagnostic imaging
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Lumbar Vertebrae/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/complications/*therapy
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Survivors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2014/09/12 06:00
MHDA- 2015/10/27 06:00
CRDT- 2014/09/12 06:00
PHST- 2014/03/01 00:00 [received]
PHST- 2014/08/27 00:00 [accepted]
PHST- 2014/09/12 06:00 [entrez]
PHST- 2014/09/12 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
AID - 10.1007/s00198-014-2878-z [doi]
PST - ppublish
SO  - Osteoporos Int. 2015 Feb;26(2):521-9. doi: 10.1007/s00198-014-2878-z. Epub 2014 
      Sep 11.