PMID- 25210857
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 9
DP  - 2014
TI  - Subfoveal choroidal thickness and glaucoma. The Beijing Eye Study 2011.
PG  - e107321
LID - 10.1371/journal.pone.0107321 [doi]
LID - e107321
AB  - PURPOSE: To examine subfoveal choroidal thickness (SFCT) in eyes with glaucoma, 
      using enhanced depth imaging spectral domain optical coherence tomography. 
      METHODS: The population-based Beijing Eye Study 2011 included 3468 individuals 
      with a mean age of 64.6 +/- 9.8 years (range: 50-93 years). A detailed ophthalmic 
      examination was performed including spectral-domain optical coherence tomography 
      (SD-OCT) with enhanced depth imaging for measurement of SFCT, and assessment of 
      fundus photographs for presence of glaucoma. In addition, the group of patients 
      with chronic angle-closure glaucoma (ACG) from the Beijing Eye Study (n = 37) was 
      merged with a group of patients with chronic ACG from the Tongren hospital (n = 
      52). RESULTS: Assessments of SFCT and glaucoma were available for 3232 (93.2%) 
      subjects. After adjusting for age, axial length, gender, anterior chamber and 
      lens thickness, SFCT was not significantly associated with presence of glaucoma 
      (P = 0.08; regression coefficient B:-15.7). As a corollary, in logistic 
      regression analysis with adjustment for age, axial length and intraocular 
      pressure, presence of glaucoma was not significantly associated with SFCT (P = 
      0.20). If only open-angle glaucoma was considered, multivariate analysis revealed 
      no significant association between SFCT and presence of open-angle glaucoma (P = 
      0.44). As a corollary, in logistic regression analysis, open-angle glaucoma was 
      not significantly associated with SFCT (P = 0.91). In a similar manner if only 
      ACG was taken into account, SFCT was not significantly associated with the 
      presence of ACG (P = 0.27) in multivariate analysis. As a corollary in binary 
      regression analysis, presence of ACG was not significantly associated with SFCT 
      (P = 0.27). CONCLUSIONS: In multivariate analysis with adjustment for age, axial 
      length, gender, anterior chamber and lens thickness, neither OAG nor ACG was 
      associated with an abnormal SFCT.
FAU - Wang, Ya Xing
AU  - Wang YX
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Xu, Liang
AU  - Xu L
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Shao, Lei
AU  - Shao L
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Zhang, Ya Qin
AU  - Zhang YQ
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Yang, Hua
AU  - Yang H
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Da Wang, Jin
AU  - Da Wang J
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Jonas, Jost B
AU  - Jonas JB
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China; Department of Ophthalmology, Medical Faculty Mannheim 
      of the Ruprecht-Karls-University, Heidelberg, Germany.
FAU - Wei, Wen Bin
AU  - Wei WB
AD  - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140911
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*pathology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fovea Centralis/pathology
MH  - Glaucoma, Angle-Closure/*pathology
MH  - Glaucoma, Open-Angle/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tomography, Optical Coherence
PMC - PMC4161421
COIS- Competing Interests: JBJ was or has been a member of advisory boards for the 
      following companies: Allergan Inc., Merck Sharp & Dohme Co., Inc., Alimera Co., 
      Boehringer Ingelheim Co. The authors state that these advisory board activities 
      did not have anything to do with the present study. This does not alter the 
      authors' adherence to all the PLOS ONE policies on sharing data and materials.
EDAT- 2014/09/12 06:00
MHDA- 2015/10/27 06:00
PMCR- 2014/09/11
CRDT- 2014/09/12 06:00
PHST- 2013/03/12 00:00 [received]
PHST- 2014/08/15 00:00 [accepted]
PHST- 2014/09/12 06:00 [entrez]
PHST- 2014/09/12 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
PHST- 2014/09/11 00:00 [pmc-release]
AID - PONE-D-13-10755 [pii]
AID - 10.1371/journal.pone.0107321 [doi]
PST - epublish
SO  - PLoS One. 2014 Sep 11;9(9):e107321. doi: 10.1371/journal.pone.0107321. 
      eCollection 2014.