PMID- 25211297
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20211021
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Print)
IS  - 1540-4196 (Linking)
VI  - 12
IP  - 10
DP  - 2014 Dec
TI  - Changes in fat distribution in children following severe burn injury.
PG  - 523-6
LID - 10.1089/met.2014.0098 [doi]
AB  - BACKGROUND: Children with severe cutaneous burn injury show persistent metabolic 
      abnormalities, including inflammation and insulin resistance. Such abnormalities 
      could potentially increase their future risk for developing type 2 diabetes 
      mellitus (T2DM) and cardiovascular disease (CVD). This could be related to 
      changes in body composition and fat distribution. METHODS: We studied body 
      composition, fat distribution, and inflammatory cytokines changes in children 
      with severe burn injury up to 6 months from discharge. Sixty-two boys and 35 
      girls (burn >/=30% of total body surface area) were included. RESULTS: We found a 
      decrease in total body fat and subcutaneous peripheral fat at 6 months (6% and 
      2%, respectively; P<0.05 each). An inverse correlation between the decrease in 
      peripheral fat content at 6 months and the extent of burn injury (r=-041, P=0.02) 
      was also observed. In addition, there was a 12% increase in serum tumor necrosis 
      factor-alpha (TNF-alpha) (P=0.01 vs. discharge) and 9% decrease in serum interleukin-10 
      (IL-10) (P<0.0001 vs. discharge) over 6 months after burn. CONCLUSION: Severe 
      burn injury in children is associated with changes in body fat content and 
      distribution up to 6 months from hospital discharge. These changes, accompanied 
      by persisting systemic inflammation, could possibly mediate the observed 
      persistence of insulin resistance, predisposing burn patients to the development 
      of T2DM and CVD.
FAU - Patel, Pavankumar
AU  - Patel P
AD  - 1 Department of Internal Medicine, The University of Texas Medical Branch , 
      Galveston, Texas.
FAU - Sallam, Hanaa S
AU  - Sallam HS
FAU - Ali, Arham
AU  - Ali A
FAU - Chandalia, Manisha
AU  - Chandalia M
FAU - Suman, Oscar
AU  - Suman O
FAU - Finnerty, Celeste C
AU  - Finnerty CC
FAU - Herndon, David N
AU  - Herndon DN
FAU - Abate, Nicola
AU  - Abate N
LA  - eng
SI  - ClinicalTrials.gov/NCT00675714
GR  - R01 HD049471/HD/NICHD NIH HHS/United States
GR  - P50-GM60338/GM/NIGMS NIH HHS/United States
GR  - R01 GM056687/GM/NIGMS NIH HHS/United States
GR  - R01-GM56687/GM/NIGMS NIH HHS/United States
GR  - R01-HD049471/HD/NICHD NIH HHS/United States
GR  - 732-GM8256/GM/NIGMS NIH HHS/United States
GR  - UL1TR000071/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140911
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (IL10 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - *Adiposity
MH  - Adolescent
MH  - Age Factors
MH  - Burns/blood/immunology/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Inflammation/blood/immunology/physiopathology
MH  - Inflammation Mediators/blood
MH  - Interleukin-10/blood
MH  - Male
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Texas
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC4291205
EDAT- 2014/09/12 06:00
MHDA- 2015/07/15 06:00
PMCR- 2015/12/01
CRDT- 2014/09/12 06:00
PHST- 2014/09/12 06:00 [entrez]
PHST- 2014/09/12 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.1089/met.2014.0098 [pii]
AID - 10.1089/met.2014.0098 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2014 Dec;12(10):523-6. doi: 10.1089/met.2014.0098. Epub 
      2014 Sep 11.