PMID- 25214251
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20211203
IS  - 0256-9574 (Print)
VI  - 104
IP  - 6
DP  - 2014 May 12
TI  - No evidence for association of insulin receptor substrate-1 Gly972Arg variant 
      with type 2 diabetes mellitus in a mixed-ancestry population of South Africa.
PG  - 420-3
LID - 10.7196/samj.7419 [doi]
AB  - BACKGROUND: The most common single-nucleotide polymorphism in the insulin 
      receptor substrate-1 (IRS1) gene is Gly972Arg, which is associated with a 25% 
      increased risk of developing diabetes. The mixed-ancestry population of South 
      Africa (SA) has one of the highest prevalences of type 2 diabetes mellitus (T2DM) 
      in Africa. OBJECTIVE: To report the frequency of IRS1 Gly972Arg and investigate 
      its associations with cardiometabolic traits. METHODS: DNA from 856 
      mixed-ancestry adults drawn from an urban community of Bellville South, Cape 
      Town, SA, was genotyped by two independent laboratories. Oral glucose tolerance 
      tests were performed and cardiometabolic risk factors measured. RESULTS: A total 
      of 237 (24.7%) participants had T2DM. The IRS1 Gly972Arg variant was present in 
      7.9% of the individuals studied and only one participant (non-diabetic) carried 
      the homozygous A/A variant. In linear and logistic regression analyses, Gly972Arg 
      was not associated with obesity, insulin resistance/sensitivity or T2DM. 
      CONCLUSIONS: The prevalence of the Gly972Arg variant in the mixed-ancestry 
      population of SA is comparable to that reported in African Americans, but its 
      presence is not associated with cardiometabolic traits. This suggests that the 
      Gly972Arg variant may not aid diabetes risk evaluation in this setting, nor can 
      such information help explain the high prevalence of diabetes previously reported 
      in this population.
FAU - Vergotine, Zelda
AU  - Vergotine Z
AD  - Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape 
      Peninsula University of Technology, Cape Town, South Africa; Division of Chemical 
      Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, 
      Tygerberg, Cape Town, South Africa. vergotinez@cput.ac.za.
FAU - Kengne, Andre Pascal
AU  - Kengne AP
FAU - Erasmus, Rajiv Timothy
AU  - Erasmus RT
FAU - Matsha, Tandi Edith
AU  - Matsha TE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140512
PL  - South Africa
TA  - S Afr Med J
JT  - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
JID - 0404520
RN  - 0 (IRS1 protein, human)
RN  - 0 (Insulin Receptor Substrate Proteins)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - S Afr Med J. 2014 Dec;104(12):837. PMID: 26042257
MH  - DNA/*genetics
MH  - Diabetes Mellitus, Type 2/blood/ethnology/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Insulin Receptor Substrate Proteins/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Native Hawaiian or Other Pacific Islander
MH  - *Polymorphism, Genetic
MH  - Prevalence
MH  - Retrospective Studies
MH  - South Africa/epidemiology
MH  - Urban Population
EDAT- 2014/09/13 06:00
MHDA- 2015/09/09 06:00
CRDT- 2014/09/13 06:00
PHST- 2013/08/26 00:00 [received]
PHST- 2013/10/17 00:00 [accepted]
PHST- 2014/09/13 06:00 [entrez]
PHST- 2014/09/13 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
AID - 10.7196/samj.7419 [doi]
PST - epublish
SO  - S Afr Med J. 2014 May 12;104(6):420-3. doi: 10.7196/samj.7419.