PMID- 2521494
OWN - NLM
STAT- MEDLINE
DCOM- 19890306
LR  - 20190709
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 20
IP  - 1
DP  - 1989 Jan
TI  - Episodic angioedema with eosinophilia.
PG  - 21-7
AB  - A 40-year-old woman had monthly episodes of angioedema, eruption of pruritic 
      papules and plaques and fever. During acute episodes white blood cell counts 
      increased to 31,000/mm3 with 75% eosinophils, body weight increased to 10% of 
      baseline weight, and urine excretion decreased to 40 ml/24 hours. No evidence was 
      found for cardiac or other visceral organ involvement. Extensive diagnostic 
      evaluations revealed no evidence for parasitic infestation, connective tissue 
      disease, or neoplastic disorders. Results of immunologic studies revealed 
      increased serum IgM and IgE levels and showed elevated levels of circulating 
      activated T-helper cells. Biopsy specimens of lesional skin showed dermal 
      infiltration of lymphocytes and eosinophils with deposition of eosinophil granule 
      major basic protein in the extracellular matrix within the dermis. 
      Immunophenotyping of the dermal infiltrate with monoclonal antibodies revealed 
      the predominance of T-helper cells, many of them expressing the human leukocyte 
      antigen (HLA)-DR, suggesting that angioedema with eosinophilia may be a T-helper 
      cell-mediated disease.
FAU - Wolf, C
AU  - Wolf C
AD  - Department of Dermatology I, University of Vienna, Medical School, Austria.
FAU - Pehamberger, H
AU  - Pehamberger H
FAU - Breyer, S
AU  - Breyer S
FAU - Leiferman, K M
AU  - Leiferman KM
FAU - Wolff, K
AU  - Wolff K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Adult
MH  - Angioedema/*complications/pathology
MH  - Eosinophilia/*complications/pathology
MH  - Female
MH  - Fever
MH  - Humans
MH  - Recurrence
MH  - T-Lymphocytes, Helper-Inducer/pathology
MH  - Weight Gain
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - S0190-9622(89)70003-7 [pii]
AID - 10.1016/s0190-9622(89)70003-7 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 1989 Jan;20(1):21-7. doi: 10.1016/s0190-9622(89)70003-7.