PMID- 25215305
OWN - NLM
STAT- MEDLINE
DCOM- 20150415
LR  - 20221207
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2014
DP  - 2014
TI  - Subjects with impaired fasting glucose: evolution in a period of 6 years.
PG  - 710370
LID - 10.1155/2014/710370 [doi]
LID - 710370
AB  - AIM: To study the evolution of impaired fasting glucose (IFG), considering 
      glucose and HbA1c levels and risk factors associated, in a period of 6 years. 
      METHODS: We studied 94 subjects with impaired fasting glucose (IFG) that were 
      diagnosed in 2005 and followed up to 2012. Glucose and HbA1c levels were 
      determined. A descriptive analysis of contingence charts was performed in order 
      to study the evolution in the development of type-2 diabetes mellitus (T2DM). 
      RESULTS: Twenty-eight of ninety-four subjects became T2DM; 51/94 remained with 
      IFG; and 20/94 presented normal fasting glucose. From the 28 diabetic subjects, 9 
      had already developed diabetes and were under treatment with oral hypoglycemic 
      agents; 5 were diagnosed with plasma glucose < 126 mg/dL, but with HbA1c over 
      6.5%. In those who developed diabetes, 15/28 had a family history of T2DM in 
      first relative degree. Also, diabetic subjects had a BMI significantly higher 
      than nodiabetics (t test: P < 0.01). The individuals that in 2005 had the highest 
      BMI are those who currently have diabetes. CONCLUSION: The IFG constitutes a 
      condition of high risk of developing T2DM in a few years, especially over 
      110 mg/dL and in obesity patients.
FAU - Leiva, E
AU  - Leiva E
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Departamento de Bioquimica Clinica e Inmunohematologia, 
      Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
FAU - Mujica, V
AU  - Mujica V
AD  - Facultad de Medicina, Universidad Catolica del Maule, Avenida San Miguel 3605, 
      3480112 Talca, Chile.
FAU - Orrego, R
AU  - Orrego R
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Departamento de Bioquimica Clinica e Inmunohematologia, 
      Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
FAU - Wehinger, S
AU  - Wehinger S
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Departamento de Bioquimica Clinica e Inmunohematologia, 
      Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
FAU - Soto, A
AU  - Soto A
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Instituto de Matematicas y Fisica, Universidad de Talca, 
      Chile 2 Norte 685, 3465548 Talca, Chile.
FAU - Icaza, G
AU  - Icaza G
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Instituto de Matematicas y Fisica, Universidad de Talca, 
      Chile 2 Norte 685, 3465548 Talca, Chile.
FAU - Vasquez, M
AU  - Vasquez M
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Departamento de Bioquimica Clinica e Inmunohematologia, 
      Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
FAU - Diaz, L
AU  - Diaz L
AD  - Programa de Investigacion de Excelencia Interdisciplinaria en Envejecimiento 
      Saludable (PIEI-ES), Departamento de Bioquimica Clinica e Inmunohematologia, 
      Facultad de Ciencias de la Salud, Universidad de Talca, 3465548 Talca, Chile.
FAU - Andrews, M
AU  - Andrews M
AD  - Laboratorio de Micronutrientes, INTA, Universidad de Chile, El Libano 5524, 
      Macul, 7830490 Santiago, Chile.
FAU - Arredondo, M
AU  - Arredondo M
AD  - Laboratorio de Micronutrientes, INTA, Universidad de Chile, El Libano 5524, 
      Macul, 7830490 Santiago, Chile.
LA  - eng
PT  - Journal Article
DEP - 20140820
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Chile/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/drug therapy/epidemiology/genetics
MH  - Disease Progression
MH  - Fasting/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Glucose Metabolism Disorders/*blood/diagnosis/drug therapy/epidemiology/genetics
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Obesity/diagnosis/epidemiology
MH  - Pedigree
MH  - Risk Factors
MH  - Time Factors
PMC - PMC4158147
EDAT- 2014/09/13 06:00
MHDA- 2015/04/16 06:00
PMCR- 2014/08/20
CRDT- 2014/09/13 06:00
PHST- 2014/06/16 00:00 [received]
PHST- 2014/08/04 00:00 [revised]
PHST- 2014/08/05 00:00 [accepted]
PHST- 2014/09/13 06:00 [entrez]
PHST- 2014/09/13 06:00 [pubmed]
PHST- 2015/04/16 06:00 [medline]
PHST- 2014/08/20 00:00 [pmc-release]
AID - 10.1155/2014/710370 [doi]
PST - ppublish
SO  - J Diabetes Res. 2014;2014:710370. doi: 10.1155/2014/710370. Epub 2014 Aug 20.