PMID- 25216506
OWN - NLM
STAT- MEDLINE
DCOM- 20150427
LR  - 20221207
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 37
IP  - 11
DP  - 2014 Nov
TI  - Early improvement predicts reduced risk of incident diabetes and improved 
      cardiovascular risk in prediabetic Asian Indian men participating in a 2-year 
      lifestyle intervention program.
PG  - 3009-15
LID - 10.2337/dc14-0407 [doi]
AB  - OBJECTIVE: Objectives of this ancillary analysis of a prospective, prevention 
      study among Asian Indians with impaired glucose tolerance (IGT) were a) to 
      quantify the reduction in incident diabetes at 24 months in participants who 
      achieved normal glucose tolerance (NGT) at 6 months (NGT-6 m) compared with the 
      other participants, b) the factors influencing the reversal to NGT at the end of 
      the study at 24 months (NGT-24 m), and c) to assess changes in cardiometabolic 
      risk factors in different categories of dysglycemia at 24 months. RESEARCH DESIGN 
      AND METHODS: Data from a 2-year primary prevention trial were used. Effect of 
      reversion to NGT-6 m on incidence of type 2 diabetes mellitus (T2DM) was analyzed 
      using the Cox proportional hazards model. Predictive variables for reversal to 
      NGT were identified using multiple logistic regression analysis. Changes in 
      cardiometabolic risk factors were estimated according to the final glycemic 
      status using fixed-effect, mixed-linear regression modeling. RESULTS: The risk of 
      T2DM in 2 years was lower by 75% in NGT-6 m group (hazard ratio 0.25 [95% CI 
      0.12-0.52]). Predictive variables for reversal to NGT-24 m were good baseline 
      beta-cell function (odds ratio [OR] 2.79 [95% CI 2.30-3.40]) and its further 
      improvement (OR 5.70 [95% CI 4.58-7.08]), and NGT-6 m (OR 2.10 [95% CI 
      1.14-3.83]). BMI decreased in those who reverted to NGT. Deterioration to T2DM 
      was associated with an increase in the levels of cardiometabolic risk factors. 
      CONCLUSIONS: Early reversion to NGT by lifestyle intervention in prediabetic men 
      was associated with a significant reduction in subsequent incidence of diabetes. 
      Good baseline beta-cell function and its further improvement and NGT-6 m were 
      associated with reversion to NGT-24 months. Reversion to NGT was associated with 
      modest improvements, whereas conversion to T2DM was associated with significant 
      worsening of the cardiometabolic risk profile.
CI  - (c) 2014 by the American Diabetes Association. Readers may use this article as long 
      as the work is properly cited, the use is educational and not for profit, and the 
      work is not altered.
FAU - Nanditha, Arun
AU  - Nanditha A
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Ram, Jagannathan
AU  - Ram J
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Snehalatha, Chamukuttan
AU  - Snehalatha C
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Selvam, Sundaram
AU  - Selvam S
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Priscilla, Susairaj
AU  - Priscilla S
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Shetty, Ananth Samith
AU  - Shetty AS
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Arun, Raghavan
AU  - Arun R
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India.
FAU - Godsland, Ian F
AU  - Godsland IF
AD  - Faculties of Medicine and Engineering, Imperial College, London, U.K.
FAU - Johnston, Desmond G
AU  - Johnston DG
AD  - Faculties of Medicine and Engineering, Imperial College, London, U.K.
FAU - Ramachandran, Ambady
AU  - Ramachandran A
AD  - India Diabetes Research Foundation and Dr. A. Ramachandran's Diabetes Hospitals, 
      Chennai, India ramachandran@vsnl.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT00819455
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140911
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Cardiovascular Diseases/epidemiology/*prevention & control
MH  - Diabetes Mellitus, Type 2/epidemiology/*prevention & control
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/epidemiology
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin-Secreting Cells/metabolism
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/physiopathology/*therapy
MH  - Prospective Studies
MH  - Risk
MH  - Risk Factors
MH  - Risk Reduction Behavior
EDAT- 2014/09/13 06:00
MHDA- 2015/04/29 06:00
CRDT- 2014/09/13 06:00
PHST- 2014/09/13 06:00 [entrez]
PHST- 2014/09/13 06:00 [pubmed]
PHST- 2015/04/29 06:00 [medline]
AID - dc14-0407 [pii]
AID - 10.2337/dc14-0407 [doi]
PST - ppublish
SO  - Diabetes Care. 2014 Nov;37(11):3009-15. doi: 10.2337/dc14-0407. Epub 2014 Sep 11.