PMID- 25216976
OWN - NLM
STAT- MEDLINE
DCOM- 20150129
LR  - 20181202
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 113
IP  - 6
DP  - 2014 Dec
TI  - Relation between eosinophilic esophagitis and oral immunotherapy for food 
      allergy: a systematic review with meta-analysis.
PG  - 624-9
LID - S1081-1206(14)00557-2 [pii]
LID - 10.1016/j.anai.2014.08.004 [doi]
AB  - BACKGROUND: The onset of eosinophilic esophagitis (EoE) after oral immunotherapy 
      (OIT) has been repeatedly described in patients with immunoglobulin E 
      (IgE)-mediated food allergy in recent years, but the relation between the 2 
      conditions has not been fully assessed and quantified. OBJECTIVE: To provide a 
      systematic review of the evidence for an association between OIT and EoE. 
      METHODS: Electronic searches were performed with keywords relating to EoE and OIT 
      in the MEDLINE, EMBASE, and SCOPUS databases. Summary estimates were calculated. 
      A fixed-effects model was used depending on heterogeneity (I(2)). Risk of 
      publication bias was assessed by funnel plot analysis and the Egger test. 
      RESULTS: The search yielded 118 documents, 15 of which were included in the 
      quantitative summary. Most reported information came from children undergoing 
      peanut, milk, and egg OIT. Significant publication bias in favor of studies 
      reporting the development of EoE after OIT was documented. The overall prevalence 
      of EoE after OIT was 2.7% (95% confidence interval 1.7%-4.0%, I(2) = 0%). 
      Differences between medium-to high-quality studies and those of low quality were 
      documented (3.5% vs 2.5%, respectively). EoE often resolved after OIT 
      discontinuation; histologic remission of EoE achieved after allergen 
      immunotherapy also was documented in 2 patients whose topical fluticasone 
      treatment failed. CONCLUSION: New onset of EoE after OIT occurs in up to 2.7% of 
      patients with IgE-mediated food allergy undergoing this treatment strategy. The 
      limited data on the utility of allergen immunotherapy as a therapy for EoE 
      prevent a recommendation for this treatment option.
CI  - Copyright (c) 2014 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Lucendo, Alfredo J
AU  - Lucendo AJ
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Ciudad 
      Real, Spain. Electronic address: alucendo@vodafone.es.
FAU - Arias, Angel
AU  - Arias A
AD  - Research Unit, Complejo Hospitalario La Mancha Centro, Alcazar de San Juan, 
      Ciudad Real, Spain.
FAU - Tenias, Jose M
AU  - Tenias JM
AD  - Research Unit, Complejo Hospitalario La Mancha Centro, Alcazar de San Juan, 
      Ciudad Real, Spain.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140910
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
SB  - IM
CIN - Ann Allergy Asthma Immunol. 2014 Dec;113(6):581-2. PMID: 25304341
MH  - Adolescent
MH  - Animals
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Egg Hypersensitivity/immunology/physiopathology/*therapy
MH  - Eosinophilic Esophagitis/*etiology/immunology/physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Milk Hypersensitivity/immunology/physiopathology/*therapy
MH  - *Models, Statistical
MH  - Peanut Hypersensitivity/immunology/physiopathology/*therapy
MH  - Sublingual Immunotherapy/*adverse effects
MH  - Treatment Outcome
EDAT- 2014/09/14 06:00
MHDA- 2015/01/30 06:00
CRDT- 2014/09/14 06:00
PHST- 2014/07/01 00:00 [received]
PHST- 2014/07/31 00:00 [revised]
PHST- 2014/08/08 00:00 [accepted]
PHST- 2014/09/14 06:00 [entrez]
PHST- 2014/09/14 06:00 [pubmed]
PHST- 2015/01/30 06:00 [medline]
AID - S1081-1206(14)00557-2 [pii]
AID - 10.1016/j.anai.2014.08.004 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2014 Dec;113(6):624-9. doi: 
      10.1016/j.anai.2014.08.004. Epub 2014 Sep 10.