PMID- 25217231
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20220317
IS  - 1432-0584 (Electronic)
IS  - 0939-5555 (Linking)
VI  - 94
IP  - 3
DP  - 2015 Mar
TI  - Comparative analysis of unrelated cord blood transplantation and HLA-matched 
      sibling hematopoietic stem cell transplantation in children with high-risk or 
      advanced acute leukemia.
PG  - 473-80
LID - 10.1007/s00277-014-2213-y [doi]
AB  - The aim of this report was to present a clinical comparison of unrelated cord 
      blood transplantation (CBT) and human leukocyte antigen (HLA)-matched sibling 
      allogeneic peripheral blood stem cell or bone marrow transplantation 
      (allo-PBSCT/BMT) in children with high-risk or advanced acute leukemia. A total 
      of 115 consecutive pediatric patients received unrelated CBT (n = 90) or sibling 
      allo-PBSCT/BMT (n = 25) between 2000 and 2012. Neutrophil and platelet recovery 
      were significantly delayed after CBT compared to allo-PBSCT/BMT. There was no 
      difference in the incidence of acute graft-versus-host disease (GVHD) or chronic 
      GVHD between the two groups. The cumulative incidence of transplant-related 
      mortality (TRM) was higher in the CBT group than in the allo-PBSCT/BMT group 
      (32.5 vs 12.8 %) (p = 0.03). The cumulative incidence of relapse was 13.1 % after 
      CBT, which was significantly lower than that of after allo-PBSCT/BMT (45.3 %) 
      (p = 0.015). The overall survival (OS) and leukemia-free survival (LFS) in the 
      CBT group were similar to those of the allo-PBSCT/BMT group; however, for acute 
      myeloid leukemia (AML) patients, the 5-year LFS in the CBT group was slightly 
      better than the allo-PBSCT/BMT group (55.7 % for CBT and 32.7 % for 
      allo-PBSCT/BMT) (p = 0.08). Our comparisons suggest that for high-risk or 
      advanced childhood acute leukemia, unrelated CBT has a higher TRM and similar 
      long-term survival, but better antileukemia effect than HLA-matched sibling 
      PBSCT/BMT. New strategies and better supportive care are required to decrease the 
      TRM of CBT.
FAU - Zheng, Changcheng
AU  - Zheng C
AD  - Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, 
      Lujiang Road No 19, Hefei, 230001, China.
FAU - Zhu, Xiaoyu
AU  - Zhu X
FAU - Tang, Baolin
AU  - Tang B
FAU - Yao, Wen
AU  - Yao W
FAU - Song, Kaidi
AU  - Song K
FAU - Tong, Juan
AU  - Tong J
FAU - Geng, Liangquan
AU  - Geng L
FAU - Liu, Huilan
AU  - Liu H
FAU - Sun, Zimin
AU  - Sun Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140913
PL  - Germany
TA  - Ann Hematol
JT  - Annals of hematology
JID - 9107334
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - *Cord Blood Stem Cell Transplantation/adverse effects
MH  - Disease Progression
MH  - Female
MH  - Graft vs Host Disease/epidemiology
MH  - Hematopoietic Stem Cell Transplantation/adverse effects/*methods
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myeloid, Acute/epidemiology/pathology/*therapy
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology/pathology/*therapy
MH  - Recurrence
MH  - Risk
MH  - Siblings
MH  - Unrelated Donors
EDAT- 2014/09/14 06:00
MHDA- 2015/04/15 06:00
CRDT- 2014/09/14 06:00
PHST- 2014/03/10 00:00 [received]
PHST- 2014/09/02 00:00 [accepted]
PHST- 2014/09/14 06:00 [entrez]
PHST- 2014/09/14 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - 10.1007/s00277-014-2213-y [doi]
PST - ppublish
SO  - Ann Hematol. 2015 Mar;94(3):473-80. doi: 10.1007/s00277-014-2213-y. Epub 2014 Sep 
      13.