PMID- 25217472
OWN - NLM
STAT- MEDLINE
DCOM- 20160929
LR  - 20211021
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 26
IP  - 1
DP  - 2016 Jan
TI  - The Default Mode Network Differentiates Biological From Non-Biological Motion.
PG  - 234-245
LID - 10.1093/cercor/bhu199 [doi]
AB  - The default mode network (DMN) has been implicated in an array of 
      social-cognitive functions, including self-referential processing, theory of 
      mind, and mentalizing. Yet, the properties of the external stimuli that elicit 
      DMN activity in relation to these domains remain unknown. Previous studies 
      suggested that motion kinematics is utilized by the brain for social-cognitive 
      processing. Here, we used functional MRI to examine whether the DMN is sensitive 
      to parametric manipulations of observed motion kinematics. Preferential responses 
      within core DMN structures differentiating non-biological from biological 
      kinematics were observed for the motion of a realistically looking, human-like 
      avatar, but not for an abstract object devoid of human form. Differences in 
      connectivity patterns during the observation of biological versus non-biological 
      kinematics were additionally observed. Finally, the results additionally suggest 
      that the DMN is coupled more strongly with key nodes in the action observation 
      network, namely the STS and the SMA, when the observed motion depicts human 
      rather than abstract form. These findings are the first to implicate the DMN in 
      the perception of biological motion. They may reflect the type of information 
      used by the DMN in social-cognitive processing.
CI  - (c) The Author 2014. Published by Oxford University Press. All rights reserved. For 
      Permissions, please e-mail: journals.permissions@oup.com.
FAU - Dayan, Eran
AU  - Dayan E
AD  - Department of Computer Science and Applied Mathematics.
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
AD  - Present Address: Human Cortical Physiology Section, National Institute of 
      Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 
      20892 USA.
FAU - Sella, Irit
AU  - Sella I
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
FAU - Mukovskiy, Albert
AU  - Mukovskiy A
AD  - Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, 
      Tubingen, Germany.
AD  - Center for Integrative Neuroscience, University Clinic Tubingen, Tubingen 72076, 
      Germany.
FAU - Douek, Yehonatan
AU  - Douek Y
AD  - Department of Computer Science and Applied Mathematics.
FAU - Giese, Martin A
AU  - Giese MA
AD  - Department of Cognitive Neurology, Hertie Institute for Clinical Brain Research, 
      Tubingen, Germany.
AD  - Center for Integrative Neuroscience, University Clinic Tubingen, Tubingen 72076, 
      Germany.
FAU - Malach, Rafael
AU  - Malach R
AD  - Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
FAU - Flash, Tamar
AU  - Flash T
AD  - Department of Computer Science and Applied Mathematics.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140912
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - *Brain Mapping
MH  - Cognition/*physiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Nerve Net/*physiology
MH  - Theory of Mind/*physiology
MH  - Young Adult
PMC - PMC4701122
OTO - NOTNLM
OT  - action-perception coupling
OT  - biological motion
OT  - default mode network
EDAT- 2014/09/14 06:00
MHDA- 2016/09/30 06:00
PMCR- 2017/01/01
CRDT- 2014/09/14 06:00
PHST- 2014/09/14 06:00 [entrez]
PHST- 2014/09/14 06:00 [pubmed]
PHST- 2016/09/30 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - bhu199 [pii]
AID - 10.1093/cercor/bhu199 [doi]
PST - ppublish
SO  - Cereb Cortex. 2016 Jan;26(1):234-245. doi: 10.1093/cercor/bhu199. Epub 2014 Sep 
      12.