PMID- 25218794
OWN - NLM
STAT- MEDLINE
DCOM- 20150824
LR  - 20211203
IS  - 1096-3634 (Electronic)
IS  - 1084-9521 (Linking)
VI  - 36
DP  - 2014 Dec
TI  - mTOR and the health benefits of exercise.
PG  - 130-9
LID - S1084-9521(14)00253-5 [pii]
LID - 10.1016/j.semcdb.2014.08.013 [doi]
AB  - Exercise is the greatest physiological stress that our bodies experience. For 
      example, during maximal endurance exercise in elite athlete's cardiac output can 
      increase up to 8-fold and the working muscles receive 21-times more blood each 
      minute than at rest. Given the physiological stress associated with exercise and 
      the adaptations that occur to handle this stress, it is not surprising that 
      exercise training is known to prevent or effectively treat a multitude of 
      degenerative conditions including cardiovascular disease, cancer, diabetes, 
      depression, Alzheimer's disease, Parkinson's disease, and many others. Many of 
      the health benefits of exercise are mediated by the mammalian/mechanistic target 
      of rapamycin (mTOR), either in complex 1 or 2, not only within the working 
      muscle, but also in distant tissues such as fat, liver, and brain. This review 
      will discuss how exercise activates mTOR in diverse tissues and the ways that 
      mTOR is important in the adaptive response that makes us bigger, stronger, and 
      healthier as a result of exercise.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Watson, Kurt
AU  - Watson K
AD  - Department of Neurobiology, Physiology, and Behavior, University of California 
      Davis, United States.
FAU - Baar, Keith
AU  - Baar K
AD  - Department of Neurobiology, Physiology, and Behavior, University of California 
      Davis, United States. Electronic address: kbaar@ucdavis.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140916
PL  - England
TA  - Semin Cell Dev Biol
JT  - Seminars in cell & developmental biology
JID - 9607332
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Brain/physiology
MH  - Cardiovascular Diseases/prevention & control
MH  - Enzyme Activation
MH  - Exercise/*physiology
MH  - Heart/physiology
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mitochondria/metabolism
MH  - Multiprotein Complexes/*metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Amino acids
OT  - Cancer
OT  - Inactivity
OT  - Longevity
OT  - Quality of life
EDAT- 2014/09/15 06:00
MHDA- 2015/08/25 06:00
CRDT- 2014/09/15 06:00
PHST- 2014/06/18 00:00 [received]
PHST- 2014/08/08 00:00 [revised]
PHST- 2014/08/22 00:00 [accepted]
PHST- 2014/09/15 06:00 [entrez]
PHST- 2014/09/15 06:00 [pubmed]
PHST- 2015/08/25 06:00 [medline]
AID - S1084-9521(14)00253-5 [pii]
AID - 10.1016/j.semcdb.2014.08.013 [doi]
PST - ppublish
SO  - Semin Cell Dev Biol. 2014 Dec;36:130-9. doi: 10.1016/j.semcdb.2014.08.013. Epub 
      2014 Sep 16.