PMID- 25219658
OWN - NLM
STAT- MEDLINE
DCOM- 20150701
LR  - 20220311
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Print)
IS  - 1567-2026 (Linking)
VI  - 11
IP  - 4
DP  - 2014
TI  - WISP1: Clinical insights for a proliferative and restorative member of the CCN 
      family.
PG  - 378-89
AB  - As a proliferative and restorative entity, Wnt1 inducible signaling pathway 
      protein 1 (WISP1) is emerging as a novel target for a number of therapeutic 
      strategies that are relevant for disorders such as traumatic injury, 
      neurodegeneration, musculoskeletal disorders, cardiovascular disease, pulmonary 
      compromise, and control of tumor growth as well as distant metastases. WISP1, a 
      target of the wingless pathway Wnt1, oversees cellular mechanisms that include 
      apoptosis, autophagy, cellular migration, stem cell proliferation, angiogenesis, 
      immune cell modulation, and tumorigenesis. The signal transduction pathways of 
      WISP1 are broad and involve phosphoinositide 3-kinase (PI 3-K), protein kinase B 
      (Akt), mitogen activated protein (MAP) kinase, c-Jun N-terminal kinase (JNK), 
      caspases, forkhead transcription factors, sirtuins, c-myc, glycogen synthase 
      kinase -3beta (GSK-3beta), beta-catenin, miRNAs, and the mechanistic target of rapamaycin 
      (mTOR). Ultimately, these signal transduction pathways of WISP1 can result in 
      varied and sometimes unpredictable outcomes especially for cell survival, tissue 
      repair, and tumorigenesis that demand increased insight into the critical role 
      WISP1 holds for cellular biology and clinical medicine.
FAU - Maiese, Kenneth
AU  - Maiese K
AD  - Cellular and Molecular Signaling, Newark, New Jersey 07101, USA. 
      wntin75@yahoo.com.
LA  - eng
GR  - R01 NS053946/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
RN  - 0 (CCN Intercellular Signaling Proteins)
RN  - 0 (CCN4 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - CCN Intercellular Signaling Proteins/metabolism/*physiology
MH  - Cell Proliferation/*physiology
MH  - Humans
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Recovery of Function/*physiology
MH  - Signal Transduction/physiology
PMC - PMC4205162
MID - NIHMS631232
COIS- CONFLICT OF INTEREST The authors confirm that this article content has no 
      conflicts of interest.
EDAT- 2014/09/16 06:00
MHDA- 2015/07/02 06:00
PMCR- 2014/10/21
CRDT- 2014/09/16 06:00
PHST- 2014/06/30 00:00 [received]
PHST- 2014/08/26 00:00 [revised]
PHST- 2014/09/03 00:00 [accepted]
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2015/07/02 06:00 [medline]
PHST- 2014/10/21 00:00 [pmc-release]
AID - CNR-EPUB-62278 [pii]
AID - 10.2174/1567202611666140912115107 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2014;11(4):378-89. doi: 10.2174/1567202611666140912115107.