PMID- 25220375
OWN - NLM
STAT- MEDLINE
DCOM- 20150626
LR  - 20220409
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 44
IP  - 11
DP  - 2014 Nov
TI  - Atopy and cause-specific mortality.
PG  - 1361-70
LID - 10.1111/cea.12408 [doi]
AB  - BACKGROUND: Atopy is the familial or personal propensity to develop 
      immunoglobulin E (IgE) antibodies against common environmental allergens and is 
      associated with high risk of allergic disease. It has been proposed that atopy 
      may have effects on risk of cardiovascular disease and cancer. OBJECTIVES: We 
      investigated the association of atopy with all-cause and cause-specific 
      mortality. METHODS: We included a total of 14 849 individuals from five Danish 
      population-based cohorts with measurements of atopy defined as serum-specific IgE 
      positivity against inhalant allergens. Participants were followed by linkage to 
      the Danish Registry of Causes of Death to obtain information on mortality status 
      and cause of death (median follow-up time 11.3 years). The relative mortality 
      risk was estimated by Cox regression and expressed as hazard ratios, HRs (95% 
      confidence intervals, CIs). RESULTS: A total of 1776 person died during 
      follow-up. The mortality risk for atopics vs. non-atopics was: for all-cause 
      mortality (HR = 1.03, 95% CI: 0.90, 1.17); neoplasms (HR = 0.86, 95% CI: 0.69, 
      1.06); endocrine, nutritional and metabolic disorders (HR = 1.48, 95% CI: 0.71, 
      3.08); mental and behavioural disorders (HR = 2.26, 95% CI: 1.18, 4.30); diseases 
      of the nervous system (HR = 1.36, 95% CI: 0.65, 2.87); diseases of the 
      circulatory system (HR = 1.00, 95% CI: 0.78, 1.29); diseases of the respiratory 
      system (HR = 0.94, 95% CI: 0.55, 1.60); and diseases of the digestive system 
      (HR = 1.75, 95% CI: 1.03, 2.98). CONCLUSIONS & CLINICAL RELEVANCE: We found no 
      statistically significant association between atopy and all-cause mortality. 
      However, atopy was associated with a significantly higher risk of dying from 
      mental and behavioural disorders and gastrointestinal diseases, particularly 
      liver diseases, and a lower risk of dying from breast cancer, but these 
      associations were not statistically significant when applying the Bonferroni 
      adjusted significance level. Further studies are needed to confirm our findings.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Skaaby, T
AU  - Skaaby T
AD  - Research Centre for Prevention and Health, Glostrup University Hospital, 
      Glostrup, Denmark.
FAU - Husemoen, L L N
AU  - Husemoen LL
FAU - Thuesen, B H
AU  - Thuesen BH
FAU - Hammer-Helmich, L
AU  - Hammer-Helmich L
FAU - Linneberg, A
AU  - Linneberg A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Cause of Death
MH  - Cohort Studies
MH  - Comorbidity
MH  - Denmark/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity, Immediate/*epidemiology/immunology/mortality
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Population Surveillance
MH  - Registries
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - atopy
OT  - breast cancer
OT  - cause-specific mortality
OT  - gastrointestinal disease
OT  - liver disease
OT  - mental and behavioural disorders
OT  - serum-specific IgE
EDAT- 2014/09/16 06:00
MHDA- 2015/06/27 06:00
CRDT- 2014/09/16 06:00
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2015/06/27 06:00 [medline]
AID - 10.1111/cea.12408 [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2014 Nov;44(11):1361-70. doi: 10.1111/cea.12408.