PMID- 25220434
OWN - NLM
STAT- MEDLINE
DCOM- 20170904
LR  - 20180102
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 281
IP  - 1
DP  - 2014 Nov 15
TI  - 2,3,4,7,8-Pentachlorodibenzofuran is far less potent than 
      2,3,7,8-tetrachlorodibenzo-p-dioxin in disrupting the pituitary-gonad axis of the 
      rat fetus.
PG  - 48-57
LID - S0041-008X(14)00326-3 [pii]
LID - 10.1016/j.taap.2014.09.001 [doi]
AB  - The effect of 2,3,4,7,8-pentachlorodibenzofuran (PnCDF) on the fetal 
      pituitary-gonad axis was compared with that produced by 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Wistar rats. Maternal treatment at 
      gestational day (GD) 15 with PnCDF and TCDD reduced the fetal expression at GD20 
      of pituitary luteinizing hormone (LH) and the testicular proteins necessary for 
      steroidogenesis. The relative potencies of PnCDF ranged from 1/42nd to 1/63rd of 
      the TCDD effect. While PnCDF, at a dose sufficient to cause a reduction in fetal 
      LH, provoked defects in sexual behavior at adulthood, a dose less than the ED50 
      failed to produce any abnormality. There was a loss of fetal body weight 
      following in utero exposure to PnCDF, and the effect of PnCDF was also much less 
      than that of TCDD. The disturbance in fetal growth was suggested to be due to a 
      reduction in the level of fetal growth hormone (GH) by dioxins. The disorder 
      caused by PnCDF/TCDD in the fetal pituitary-gonad axis occurred at doses less 
      than those needed to cause wasting syndrome in pubertal rats. The harmful effect 
      of PnCDF relative to TCDD was more pronounced in fetal rats than in pubertal 
      rats. These lines of evidence suggest that: 1) PnCDF as well as TCDD imprints 
      defects in sexual behavior by disrupting the fetal pituitary-gonad axis; 2) these 
      dioxins hinder fetal growth by reducing the expression of fetal GH; and 3) the 
      fetal effects of PnCDF/TCDD are more sensitive than sub-acute toxicity during 
      puberty, and the relative effect of PnCDF varies markedly depending on the 
      indices used.
CI  - Copyright (c) 2014. Published by Elsevier Inc.
FAU - Taura, Junki
AU  - Taura J
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
FAU - Takeda, Tomoki
AU  - Takeda T
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
FAU - Fujii, Misaki
AU  - Fujii M
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
FAU - Hattori, Yukiko
AU  - Hattori Y
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
FAU - Ishii, Yuji
AU  - Ishii Y
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
FAU - Kuroki, Hiroaki
AU  - Kuroki H
AD  - Daiichi University of Pharmacy, Fukuoka, Japan.
FAU - Tsukimori, Kiyomi
AU  - Tsukimori K
AD  - Department of Obstetrics, Fukuoka Children's Hospital, Fukuoka, Japan.
FAU - Uchi, Hiroshi
AU  - Uchi H
AD  - Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, 
      Fukuoka, Japan.
FAU - Furue, Masutaka
AU  - Furue M
AD  - Research and Clinical Center for Yusho and Dioxin, Kyushu University Hospital, 
      Fukuoka, Japan; Graduate School of Medical Sciences, Kyushu University, Fukuoka, 
      Japan.
FAU - Yamada, Hideyuki
AU  - Yamada H
AD  - Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan. 
      Electronic address: hyamada@phar.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140916
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzofurans)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - U4C2RV3124 (2,3,4,7,8-pentachlorodibenzofuran)
SB  - IM
MH  - Animals
MH  - Benzofurans/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Environmental Pollutants/toxicity
MH  - Female
MH  - Fetal Development/drug effects/physiology
MH  - Fetus/*drug effects/metabolism
MH  - Luteinizing Hormone/blood
MH  - Male
MH  - Maternal Exposure
MH  - Pituitary Gland/*drug effects/metabolism
MH  - Polychlorinated Dibenzodioxins/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Sexual Behavior, Animal/*drug effects/physiology
MH  - Testis/*drug effects/physiology
OTO - NOTNLM
OT  - 2,3,4,7,8-Pentachlorodibenzofuran (PnCDF)
OT  - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
OT  - Fetus
OT  - Gonadotropin
OT  - Steroidogenesis
OT  - Toxic equivalency factor (TEF)
EDAT- 2014/09/16 06:00
MHDA- 2014/09/16 06:01
CRDT- 2014/09/16 06:00
PHST- 2014/03/27 00:00 [received]
PHST- 2014/07/19 00:00 [revised]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2014/09/16 06:01 [medline]
AID - S0041-008X(14)00326-3 [pii]
AID - 10.1016/j.taap.2014.09.001 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2014 Nov 15;281(1):48-57. doi: 
      10.1016/j.taap.2014.09.001. Epub 2014 Sep 16.