PMID- 25220445
OWN - NLM
STAT- MEDLINE
DCOM- 20150629
LR  - 20141021
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 84
IP  - 5
DP  - 2014 Nov
TI  - Three hundred and seventy-two novel HLA class II alleles identified in potential 
      hematopoietic stem cell donors from Germany, the United States, and Poland.
PG  - 497-502
LID - 10.1111/tan.12432 [doi]
AB  - We have characterized 372 novel human leukocyte antigen (HLA) class II alleles 
      identified in newly registered stem cell donors, this includes 281 HLA-DRB1 
      alleles, 89 HLA-DQB1 alleles and 2 HLA-DPB1 alleles. Most novel alleles were 
      single nucleotide variants when compared to their respective most homologous 
      alleles. In 66.4% of all novel alleles non-synonymous nucleotide variations were 
      identified, in 30.4% synonymous substitutions and in 3.2% nonsense mutations. 
      Ninty-three (25.0%) novel alleles were found in several individuals; most often 
      these were novel HLA-DRB1 alleles. Lastly, we underline the importance of 
      recruiting ethnic minority donors in countries such as Germany and the United 
      States, as novel alleles were frequently found among these groups.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Hernandez-Frederick, C J
AU  - Hernandez-Frederick CJ
AD  - DKMS German Bone Marrow Donor Center, Tubingen, Germany.
FAU - Cereb, N
AU  - Cereb N
FAU - Giani, A S
AU  - Giani AS
FAU - Ruppel, J
AU  - Ruppel J
FAU - Maraszek, A
AU  - Maraszek A
FAU - Pingel, J
AU  - Pingel J
FAU - Sauter, J
AU  - Sauter J
FAU - Schmidt, A H
AU  - Schmidt AH
FAU - Yang, S Y
AU  - Yang SY
LA  - eng
PT  - Journal Article
DEP - 20140912
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Codon, Nonsense)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - *Alleles
MH  - Codon, Nonsense
MH  - Female
MH  - *Gene Frequency
MH  - Germany
MH  - HLA-DP beta-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Living Donors
MH  - Male
MH  - Poland
MH  - United States
OTO - NOTNLM
OT  - genetic diversity
OT  - hematopoietic stem cell transplantation
OT  - human leukocyte antigens
OT  - new alleles
OT  - sequencing-based typing
EDAT- 2014/09/16 06:00
MHDA- 2015/06/30 06:00
CRDT- 2014/09/16 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/07/22 00:00 [revised]
PHST- 2014/07/30 00:00 [accepted]
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2015/06/30 06:00 [medline]
AID - 10.1111/tan.12432 [doi]
PST - ppublish
SO  - Tissue Antigens. 2014 Nov;84(5):497-502. doi: 10.1111/tan.12432. Epub 2014 Sep 
      12.