PMID- 25221473
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140915
LR  - 20220331
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 8
DP  - 2014
TI  - BDNF signaling and survival of striatal neurons.
PG  - 254
LID - 10.3389/fncel.2014.00254 [doi]
LID - 254
AB  - The striatum, a major component of the basal ganglia, performs multiple functions 
      including control of movement, reward, and addiction. Dysfunction and death of 
      striatal neurons are the main causes for the motor disorders associated with 
      Huntington's disease (HD). Brain-derived neurotrophic factor (BDNF), a member of 
      the neurotrophin family, is among factors that promote survival and proper 
      function of this neuronal population. Here, we review recent studies showing that 
      BDNF determines the size of the striatum by supporting survival of the immature 
      striatal neurons at their origin, promotes maturation of striatal neurons, and 
      facilitates establishment of striatal connections during brain development. We 
      also examine the role of BDNF in maintaining proper function of the striatum 
      during adulthood, summarize the mechanisms that lead to a deficiency in BDNF 
      signaling and subsequently striatal degeneration in HD, and highlight a potential 
      role of BDNF as a therapeutic target for HD treatment.
FAU - Baydyuk, Maryna
AU  - Baydyuk M
AD  - National Institute of Neurological Diseases and Stroke, National Institutes of 
      Health Bethesda, MD, USA.
FAU - Xu, Baoji
AU  - Xu B
AD  - Department of Neuroscience, The Scripps Research Institute Florida Jupiter, FL, 
      USA.
LA  - eng
GR  - R01 NS050596/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20140828
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4147651
OTO - NOTNLM
OT  - BDNF
OT  - DRD1a
OT  - DRD2
OT  - Huntington's disease
OT  - TrkB
OT  - dopaminergic neurons
OT  - neurotrophins
OT  - striatum
EDAT- 2014/09/16 06:00
MHDA- 2014/09/16 06:01
PMCR- 2014/01/01
CRDT- 2014/09/16 06:00
PHST- 2014/05/21 00:00 [received]
PHST- 2014/08/11 00:00 [accepted]
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2014/09/16 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2014.00254 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2014 Aug 28;8:254. doi: 10.3389/fncel.2014.00254. 
      eCollection 2014.