PMID- 25221715
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140915
LR  - 20220409
IS  - 2141-9248 (Print)
IS  - 2277-9205 (Electronic)
IS  - 2141-9248 (Linking)
VI  - 4
IP  - 4
DP  - 2014 Jul
TI  - Virtual Elimination of Mother-to-Child Transmission of Human Immunodeficiency 
      Virus in Mothers on Highly Active Antiretroviral Therapy in Enugu, South-Eastern 
      Nigeria.
PG  - 615-8
LID - 10.4103/2141-9248.139344 [doi]
AB  - BACKGROUND: With the current World Health Organization (WHO) "Option B+" for 
      prevention of mother to child transmission (PMTCT) of human immunodeficiency 
      virus (HIV), virtual elimination of mother to child transmission (eMTCT) is 
      highly achievable. AIM: The aim of this study is to determine the rate of MTCT of 
      HIV from mothers who started highly active antiretroviral therapy (HAART) for 
      life from diagnosis during pregnancy to the exposed babies who had daily 
      nevirapine in the first 6 weeks of life. SUBJECTS AND METHODS: HIV positive 
      mothers and their exposed babies who enrolled for the hospital PMTCT protocol 
      from January 1, 2009 to December 31, 2011 were studied. The babies were tested 
      for HIV using deoxyribo nucleic acid polymerase chain reaction test at 6 weeks, 
      and then HIV rapid tests at 18 months. RESULTS: A total of 5,946 booked mothers 
      had HIV testing and counseling (HTC) within the study period. Two hundred and 
      twenty-three (223/5946, 3.7%) were positive, out of which 188 (188/223, 84.3%) 
      enrolled for the PMTCT interventions while 35 (35/223, 15.7%) did not enroll. 
      Three of the enrollees were lost to follow up and two were referred to another 
      PMCT center. Of the remaining 183 enrolled HIV positive mothers, one gave birth 
      to a set of twins, giving a total of 184 exposed babies. There were two cases of 
      intrauterine fetal death of unknown fetal HIV status. None of the 182 remaining 
      babies evaluated for HIV testing tested positive to HIV. CONCLUSIONS: With 
      adequate suppression of maternal viral replication with HAART using the WHO 
      Option B+, eMTCT of HIV is achievable in a developing country like Nigeria where 
      infant breastfeeding is a norm.
FAU - Okafor, Ii
AU  - Okafor I
AD  - Department of Obstetrics and Gynecology, Enugu State University of Science and 
      Technology Teaching Hospital, Parklane, Enugu, Nigeria.
FAU - Ugwu, Eo
AU  - Ugwu E
AD  - Department of Obstetrics and Gynecology, College of Medicine, University of 
      Nigeria, Enugu, Enugu State, Enugu Campus/University of Nigeria Teaching 
      Hospital, Ituku/Ozalla, Enugu, Nigeria.
FAU - Obi, Sn
AU  - Obi S
AD  - Department of Obstetrics and Gynecology, College of Medicine, University of 
      Nigeria, Enugu, Enugu State, Enugu Campus/University of Nigeria Teaching 
      Hospital, Ituku/Ozalla, Enugu, Nigeria.
FAU - Odugu, Bu
AU  - Odugu B
AD  - Department of Obstetrics and Gynecology, Enugu State University of Science and 
      Technology Teaching Hospital, Parklane, Enugu, Nigeria.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Med Health Sci Res
JT  - Annals of medical and health sciences research
JID - 101585351
PMC - PMC4160691
OTO - NOTNLM
OT  - Developing country
OT  - Elimination of mother to child transmission
OT  - Highly active antiretroviral therapy
OT  - Human immunodeficiency virus
COIS- Conflict of Interest: None declared.
EDAT- 2014/09/16 06:00
MHDA- 2014/09/16 06:01
PMCR- 2014/07/01
CRDT- 2014/09/16 06:00
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2014/09/16 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - AMHSR-4-615 [pii]
AID - 10.4103/2141-9248.139344 [doi]
PST - ppublish
SO  - Ann Med Health Sci Res. 2014 Jul;4(4):615-8. doi: 10.4103/2141-9248.139344.