PMID- 25221765
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140915
LR  - 20211021
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 3
DP  - 2014
TI  - Effectiveness of itraconazole on clinical symptoms and radiologic findings in 
      patients with recurrent chronic rhinosinusitis and nasal polyposis.
PG  - 162
LID - 10.4103/2277-9175.139124 [doi]
LID - 162
AB  - BACKGROUND: This study was done to evaluate the effect of itraconazole on 
      clinical symptoms and radiologic findings in patients with chronic rhinosinusitis 
      and nasal polyposis after surgery. MATERIALS AND METHODS: In a clinical trial 
      which was conducted in Alzahra and Kashani hospitals, from November 2011 to 
      December 2012, 22 patients with recurrent postsurgical chronic sinusitis and 
      polyposis entered the study. At the start of the study demographic data, 
      subjective clinical symptoms (severity of rhinorrhea, nasal obstruction, 
      hyposmia, and dyspnea), quality of life (QoL) by sinonasal outcome test-20 
      (SNOT-20), serum immunoglobulin E (IgE), and score of computed tomography (CT) 
      scan (by Lund-Mackay) were recorded. Itraconazole (100 mg, twice per day) 
      prescribed for 3 months and patients were followed in the 1(st), 3(rd), and 6(th) 
      months. Liver enzyme tests and side effects were evaluated monthly. RESULTS: 
      Severity of rhinorrhea, nasal obstruction, hyposmia, dyspnea, and QoL (by 
      SNOT-20) improved during 3 months of treatment. Serum IgE was 265 (+/-277) at the 
      start of the study, and decrease to 193 (+/-183) after 3 month. After 3 month, 
      Lund-Mackay score of CT scan lowered from 19 (+/-4) to 15 (+/-6) (P < 0.05). At the 
      6(th) month, severity of clinical symptoms except dyspnea and QoL were better 
      than first evaluation. CONCLUSION: This study showed the beneficial effect of 
      3-month itraconazole treatment on clinical symptoms and radiologic findings and 
      QoL in patients with recurrent postsurgical chronic rhinosinusitis and nasal 
      polyposis.
FAU - Hashemi, Mostafa
AU  - Hashemi M
AD  - Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Fereidani, Akram
AU  - Fereidani A
AD  - Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Berjis, Nezamoddin
AU  - Berjis N
AD  - Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Okhovat, Sayyed Ahmad Reza
AU  - Okhovat SA
AD  - Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
FAU - Eshaghain, Afrooz
AU  - Eshaghain A
AD  - Department of Otorhinolaryngology, Kashani Hospital, Isfahan University of 
      Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20140819
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC4162036
OTO - NOTNLM
OT  - Chronic rhinosinusitis
OT  - itraconazole
OT  - nasal polyposis
COIS- Conflict of Interest: None declared.
EDAT- 2014/09/16 06:00
MHDA- 2014/09/16 06:01
PMCR- 2014/08/19
CRDT- 2014/09/16 06:00
PHST- 2013/02/04 00:00 [received]
PHST- 2013/05/05 00:00 [accepted]
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2014/09/16 06:01 [medline]
PHST- 2014/08/19 00:00 [pmc-release]
AID - ABR-3-162 [pii]
AID - 10.4103/2277-9175.139124 [doi]
PST - epublish
SO  - Adv Biomed Res. 2014 Aug 19;3:162. doi: 10.4103/2277-9175.139124. eCollection 
      2014.