PMID- 25222078
OWN - NLM
STAT- MEDLINE
DCOM- 20160923
LR  - 20161126
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 17
IP  - 2
DP  - 2016 Feb
TI  - Left atrial function in cardiac amyloidosis.
PG  - 113-21
LID - 10.2459/JCM.0000000000000188 [doi]
AB  - AIMS: Left atrium can be involved by amyloid deposition in familial amyloid 
      polyneuropathy (FAP). The aim of our study is to assess left atrium function in 
      atrial amyloidosis. METHODS: Twenty-eight FAP patients (53 +/- 12 years) and a 
      control group of 22 asymptomatic individuals (49 +/- 11 years) underwent strain 
      echocardiography and cardiac magnetic resonance (CMR). CMR by late gadolinium 
      enhancement (LGE) was used to assess the left atrium amyloid deposition, whereas 
      strain echocardiography was used to quantify the left atrium deformation. The 
      following atrial longitudinal strain (ALS) parameters were assessed: peak at the 
      end of ventricular systole (peak-ALS), peak at early diastole (early-ALS), 
      negative peak in late diastole, precontraction (prec)-ALS (difference between 
      peak-ALS and early-ALS), and late ALS (sum of negative peak and prec-ALS). 
      RESULTS: CMR showed atrial LGE in 14 FAP patients (LGE-atrial group), whereas 14 
      FAP patients showed no LGE (no-LGE-atrial group). Peak-ALS was significantly 
      lower in the LGE-atrial group (22.8 +/- 13%) compared with the no-LGE-atrial group 
      (59.6 +/- 33.1%; P = 0.001) and controls (47.4 +/- 16.4%; P = 0.001). Early-ALS was 
      lower in the LGE-atrial group (10.2 +/- 6.2%) compared with the controls 
      (26.3 +/- 11.9%; P = 0.02) and the no-LGE-atrial group (30.2 +/- 22.4%; P = 0.01). 
      Prec-ALS was lower (P = 0.001) in the LGE-atrial group (12.6 +/- 7.8%) compared 
      with the no-LGE-atrial group (26.2 +/- 15%). Conversely, late-ALS was higher 
      (P = 0.04) in the no-LGE-atrial group (22.8 +/- 12.3%) compared with the controls 
      (13.9 +/- 9%); no significant differences were found in the negative peak among 
      groups. CONCLUSIONS: Patients with atrial amyloidosis have an adverse left atrium 
      remodeling associated with left atrium dysfunction. Left atrium assessment may 
      provide useful information in the clinical and prognostic stratification of 
      amyloidotic patients.
FAU - Di Bella, Gianluca
AU  - Di Bella G
AD  - aClinical and Experimental Department of Medicine bDepartment of Biomedical 
      Sciences and of Morphologic and Functional Images cDepartment of Neurosciences, 
      Psychiatry and Anaesthesiology, University of Messina, Messina dDepartment of 
      Cardiac MRI, Fondazione CNR-Regione Toscana 'G. Monasterio,' Pisa eInstitute of 
      Clinical Physiology, CNR Pisa fEsaote, Florence, Italy.
FAU - Minutoli, Fabio
AU  - Minutoli F
FAU - Madaffari, Antonio
AU  - Madaffari A
FAU - Mazzeo, Anna
AU  - Mazzeo A
FAU - Russo, Massimo
AU  - Russo M
FAU - Donato, Rocco
AU  - Donato R
FAU - Zito, Concetta
AU  - Zito C
FAU - Aquaro, Giovanni D
AU  - Aquaro GD
FAU - Piccione, Maurizio Cusma
AU  - Piccione MC
FAU - Pedri, Stefano
AU  - Pedri S
FAU - Vita, Giuseppe
AU  - Vita G
FAU - Pingitore, Alessandro
AU  - Pingitore A
FAU - Carerj, Scipione
AU  - Carerj S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloidosis/blood/diagnostic imaging/*physiopathology
MH  - *Atrial Function, Left
MH  - Case-Control Studies
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Diseases/blood/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
EDAT- 2014/09/16 06:00
MHDA- 2016/09/24 06:00
CRDT- 2014/09/16 06:00
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2016/09/24 06:00 [medline]
AID - 10.2459/JCM.0000000000000188 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2016 Feb;17(2):113-21. doi: 
      10.2459/JCM.0000000000000188.