PMID- 25222300
OWN - NLM
STAT- MEDLINE
DCOM- 20141224
LR  - 20211021
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 73
DP  - 2014 Dec
TI  - Exposure to persistent organic pollutants and sperm sex chromosome ratio in men 
      from the Faroe Islands.
PG  - 359-64
LID - S0160-4120(14)00267-0 [pii]
LID - 10.1016/j.envint.2014.09.001 [doi]
AB  - People in the Arctic as well as fishermen on the polluted Swedish east coast are 
      highly exposed to persistent organic pollutants (POPs). These compounds have been 
      shown to affect the sperm Y:X chromosome ratio. In present study, the aim was to 
      investigate whether polychlorinated biphenyl (PCB) congeners and 
      1,1,-dichloro-2,2,-bis(p-chlorophenyl)ethane (p,p'-DDE) influence sperm sex 
      chromosome ratio in Faroese men, and whether these men differ regarding Y:X ratio 
      compared to Greenland Inuit and Swedish fishermen. The study population (n=449) 
      consisted of young men from the general population (n=276) as well as proven 
      fertile men (n=173). The Y:X ratio was assessed by fluorescent in situ 
      hybridization. Serum concentrations of POPs were measured using gas 
      chromatography. Associations between POP concentrations and Y:X ratio were 
      calculated using linear and non-linear regression models as well as trend 
      analysis and pairwise comparison of exposure data categorized into quartiles. The 
      selected POPs were associated with Y:X ratio in fertile Faroese men, but not in 
      the total population; p,p'-DDE (95% CI for B=-0.005 to -0.001, p=0.005) and SigmaPCB 
      (95% CI for B=-0.005 to -0.001, p=0.012). Since p,p'-DDE and SigmaPCB correlated 
      significantly (r=0.927, p<0.001), the results involving the exposure variables 
      can be regarded as a single finding. The Y:X ratio for the total Faroese 
      population was 0.500+/-0.018, which was statistically significantly lower than in 
      both Inuit and Swedish fishermen (0.512 for both). In conclusion, Faroese men 
      presented with lower Y:X ratio than Greenland Inuit and Swedish fishermen. 
      Although no direct health effects are expected due to the lower Faroese Y:X 
      ratio, it could be indicative of adverse effects on the reproductive system.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Kvist, L
AU  - Kvist L
AD  - Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund 
      University, Malmo 20502, Sweden. Electronic address: Linus.Kvist@med.lu.se.
FAU - Giwercman, A
AU  - Giwercman A
AD  - Reproductive Medicine Centre, Skane University Hospital, Malmo 20502, Sweden; 
      Department of Clinical Sciences, Molecular Reproductive Research, Lund 
      University, Malmo 20502, Sweden.
FAU - Weihe, P
AU  - Weihe P
AD  - Department of Occupational Medicine and Public Health, Faroese Hospital System, 
      Torshavn FO-110, Faroe Islands.
FAU - Kold Jensen, T
AU  - Kold Jensen T
AD  - Department of Environmental Medicine, Institute of Public Health, University of 
      Southern Denmark, Odense DK-5000, Denmark; Department of Growth and Reproduction, 
      National Hospital, Copenhagen DK-2100, Denmark.
FAU - Grandjean, P
AU  - Grandjean P
AD  - Department of Environmental Medicine, Institute of Public Health, University of 
      Southern Denmark, Odense DK-5000, Denmark; Department of Environmental Health, 
      Harvard School of Public Health, Boston, MA 02115, United States.
FAU - Halling, J
AU  - Halling J
AD  - Department of Clinical Pharmacology, University of Southern Denmark, Odense 
      DK-5000, Denmark.
FAU - Skaalum Petersen, M
AU  - Skaalum Petersen M
AD  - Department of Occupational Medicine and Public Health, Faroese Hospital System, 
      Torshavn FO-110, Faroe Islands.
FAU - Lundberg Giwercman, Y
AU  - Lundberg Giwercman Y
AD  - Department of Clinical Sciences, Molecular Genetic Reproductive Medicine, Lund 
      University, Malmo 20502, Sweden.
LA  - eng
GR  - ES09797/ES/NIEHS NIH HHS/United States
GR  - R01 ES014460/ES/NIEHS NIH HHS/United States
GR  - ES012199/ES/NIEHS NIH HHS/United States
GR  - R01 ES012199/ES/NIEHS NIH HHS/United States
GR  - R01 ES009797/ES/NIEHS NIH HHS/United States
GR  - U01 ES009797/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140916
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - *Chromosomes, Human, X
MH  - *Chromosomes, Human, Y
MH  - Denmark
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*blood
MH  - Greenland
MH  - Humans
MH  - Male
MH  - Polychlorinated Biphenyls/blood
MH  - Spermatozoa/chemistry
MH  - Sweden
PMC - PMC4413009
MID - NIHMS683027
OTO - NOTNLM
OT  - PCB
OT  - Persistent organic pollutants
OT  - Y:X ratio
OT  - p,p'-DDE
EDAT- 2014/09/16 06:00
MHDA- 2014/12/30 06:00
PMCR- 2015/04/29
CRDT- 2014/09/16 06:00
PHST- 2014/05/19 00:00 [received]
PHST- 2014/08/26 00:00 [revised]
PHST- 2014/09/01 00:00 [accepted]
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2014/12/30 06:00 [medline]
PHST- 2015/04/29 00:00 [pmc-release]
AID - S0160-4120(14)00267-0 [pii]
AID - 10.1016/j.envint.2014.09.001 [doi]
PST - ppublish
SO  - Environ Int. 2014 Dec;73:359-64. doi: 10.1016/j.envint.2014.09.001. Epub 2014 Sep 
      16.