PMID- 25222779
OWN - NLM
STAT- MEDLINE
DCOM- 20150409
LR  - 20211021
IS  - 0971-5916 (Print)
IS  - 0975-9174 (Electronic)
IS  - 0971-5916 (Linking)
VI  - 140
IP  - 1
DP  - 2014 Jul
TI  - Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene 
      polymorphisms in type 2 diabetes.
PG  - 60-8
AB  - BACKGROUND & OBJECTIVES: Diabetes is a metabolic pro-inflammatory disorder 
      characterized by chronic hyperglycaemia and increased levels of circulating 
      cytokines suggesting a causal role for inflammation in its aetiology. In order to 
      decipher the role of interleukin-6 (IL-6) in type 2 diabetes mellitus (T2DM) we 
      analyzed two promoter polymorphisms -597 A/G (rs1800797) and -174 G/C (rs1800795) 
      in T2DM cases from north India, and in healthy controls. METHODS: DNA was 
      isolated from venous blood samples of T2DM patients (n=213) and normal healthy 
      controls (n=145). Polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) was performed after biochemical analysis. The genotypic 
      and allelic frequency distributions were analyzed. RESULTS: The 
      clinical/biochemical parameters of T2DM cases when compared to controls showed a 
      significant difference. No significant association was observed with -597A/G 
      polymorphism while, -174 G/C showed a highly significant association (P<0.001). 
      In haplotypic analysis, combination of -597GFNx01/-174CFNx01 showed significant 
      association (P=0.010). INTERPRETATION & CONCLUSIONS: Our data suggest that IL-6 
      gene polymorphisms play a prominent role in T2DM disease susceptibility in 
      population from north India.
FAU - Saxena, Madhukar
AU  - Saxena M
FAU - Agrawal, C G
AU  - Agrawal CG
FAU - Srivastava, Neena
AU  - Srivastava N
FAU - Banerjee, Monisha
AU  - Banerjee M
AD  - Department of Zoology, University of Lucknow, Lucknow, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Base Sequence
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Components
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Haplotypes/genetics
MH  - Humans
MH  - India
MH  - Interleukin-6/*genetics
MH  - Male
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
PMC - PMC4181162
EDAT- 2014/09/16 06:00
MHDA- 2015/04/10 06:00
PMCR- 2014/07/01
CRDT- 2014/09/16 06:00
PHST- 2014/09/16 06:00 [entrez]
PHST- 2014/09/16 06:00 [pubmed]
PHST- 2015/04/10 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - IndianJMedRes_2014_140_1_60_139992 [pii]
AID - IJMR-140-60 [pii]
PST - ppublish
SO  - Indian J Med Res. 2014 Jul;140(1):60-8.