PMID- 25224208
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20190606
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Linking)
VI  - 53
IP  - 18
DP  - 2014
TI  - Hepatitis B virus-related immune reconstitution inflammatory syndrome in two 
      patients coinfected with human immunodeficiency virus diagnosed with a liver 
      biopsy.
PG  - 2165-70
AB  - Hepatic flares occurred in two patients with HBV/HIV coinfection following the 
      commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV 
      DNA levels had decreased. The results of liver biopsies showed lymphocytic 
      infiltration that was diffusely positive for CD8(+) T cells in the portal areas 
      and lobules. These findings suggested HBV-related immune reconstitution 
      inflammatory syndrome (IRIS). The alanine aminotransferase levels of both 
      patients gradually decreased with the continuation of ART. Because there are few 
      reports of the liver histology of HBV-related IRIS, these cases provide a better 
      understanding of the pathogenesis of HBV-related IRIS.
FAU - Mitsumoto, Fujiko
AU  - Mitsumoto F
AD  - Department of General Internal Medicine, Kyushu University Hospital, Japan.
FAU - Murata, Masayuki
AU  - Murata M
FAU - Kato, Yoshifumi
AU  - Kato Y
FAU - Ura, Kazuya
AU  - Ura K
FAU - Takayama, Koji
AU  - Takayama K
FAU - Hiramine, Satoshi
AU  - Hiramine S
FAU - Ikezaki, Hiroaki
AU  - Ikezaki H
FAU - Shimizu, Motohiro
AU  - Shimizu M
FAU - Toyoda, Kazuhiro
AU  - Toyoda K
FAU - Ogawa, Eiichi
AU  - Ogawa E
FAU - Aishima, Shinichi
AU  - Aishima S
FAU - Furusyo, Norihiro
AU  - Furusyo N
FAU - Hayashi, Jun
AU  - Hayashi J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140915
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (DNA, Viral)
RN  - 0 (Hepatitis B Antibodies)
SB  - IM
MH  - Adult
MH  - Biopsy/*methods
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Coinfection
MH  - DNA, Viral/analysis
MH  - Diagnosis, Differential
MH  - HIV/*genetics
MH  - HIV Infections/diagnosis/*immunology/virology
MH  - Hepatitis B Antibodies/analysis
MH  - Hepatitis B virus/genetics/*immunology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/diagnosis/*immunology/virology
MH  - Liver/*pathology/virology
MH  - Male
MH  - Young Adult
EDAT- 2014/09/17 06:00
MHDA- 2015/05/13 06:00
CRDT- 2014/09/17 06:00
PHST- 2014/09/17 06:00 [entrez]
PHST- 2014/09/17 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - DN/JST.JSTAGE/internalmedicine/53.2503 [pii]
AID - 10.2169/internalmedicine.53.2503 [doi]
PST - ppublish
SO  - Intern Med. 2014;53(18):2165-70. doi: 10.2169/internalmedicine.53.2503. Epub 2014 
      Sep 15.