PMID- 25224451
OWN - NLM
STAT- MEDLINE
DCOM- 20150715
LR  - 20211021
IS  - 1759-4820 (Electronic)
IS  - 1759-4812 (Print)
IS  - 1759-4812 (Linking)
VI  - 11
IP  - 10
DP  - 2014 Oct
TI  - Brain-derived neurotrophic factor in urinary continence and incontinence.
PG  - 579-88
LID - 10.1038/nrurol.2014.244 [doi]
AB  - Urinary incontinence adversely affects quality of life and results in an 
      increased financial burden for the elderly. Accumulating evidence suggests a 
      connection between neurotrophins, such as brain-derived neurotrophic factor 
      (BDNF), and lower urinary tract function, particularly with regard to normal 
      physiological function and the pathophysiological mechanisms of stress urinary 
      incontinence (SUI) and bladder pain syndrome/interstitial cystitis (BPS/IC). The 
      interaction between BDNF and glutamate receptors affects both bladder and 
      external urethral sphincter function during micturition. Clinical findings 
      indicate reduced BDNF levels in antepartum and postpartum women, potentially 
      correlating with postpartum SUI. Experiments with animal models demonstrate that 
      BDNF is decreased after simulated childbirth injury, thereby impeding the 
      recovery of injured nerves and the restoration of continence. Treatment with 
      exogenous BDNF facilitates neural recovery and the restoration of continence. 
      Serotonin and noradrenaline reuptake inhibitors, used to treat both depression 
      and SUI, result in enhanced BDNF levels. Understanding the neurophysiological 
      roles of BDNF in maintaining normal urinary function and in the pathogenesis of 
      SUI and BPS/IC could lead to future therapies based on these mechanisms.
FAU - Song, Qi-Xiang
AU  - Song QX
AD  - Department of Urology, Changhai Hospital, Shanghai, PR China.
FAU - Chermansky, Christopher J
AU  - Chermansky CJ
AD  - Department of Urology, University of Pittsburgh School of Medicine, 3550 Terrace 
      Street, Pittsburgh, PA 15261, USA.
FAU - Birder, Lori A
AU  - Birder LA
AD  - Department of Medicine, University of Pittsburgh School of Medicine, 3550 Terrace 
      Street, Pittsburgh, PA 15261, USA.
FAU - Li, Longkun
AU  - Li L
AD  - Department of Urology, Second Affiliated Hospital of TMMU, Chongqing, PR China.
FAU - Damaser, Margot S
AU  - Damaser MS
AD  - Department of Biomedical Engineering, The Cleveland Clinic, 9500 Euclid Avenue 
      ND20, Cleveland, OH 44195, USA.
LA  - eng
GR  - F9261-L/RD/ORD VA/United States
GR  - I01 RX000228/RX/RRD VA/United States
GR  - I01 RX001262/RX/RRD VA/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20140916
PL  - England
TA  - Nat Rev Urol
JT  - Nature reviews. Urology
JID - 101500082
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Glutamate)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/drug effects/*metabolism/physiology
MH  - Cystitis, Interstitial/metabolism
MH  - Female
MH  - Humans
MH  - Quality of Life
MH  - Receptors, Glutamate/metabolism
MH  - Urethra/*metabolism/physiology/physiopathology
MH  - Urinary Bladder/*metabolism/physiology/physiopathology
MH  - Urinary Incontinence/metabolism/physiopathology
MH  - Urinary Incontinence, Stress/drug therapy/*metabolism/physiopathology
MH  - Urinary Tract/metabolism/physiopathology
MH  - Urination/physiology
PMC - PMC6946056
MID - NIHMS1057130
EDAT- 2014/09/17 06:00
MHDA- 2015/07/16 06:00
PMCR- 2020/01/07
CRDT- 2014/09/17 06:00
PHST- 2014/09/17 06:00 [entrez]
PHST- 2014/09/17 06:00 [pubmed]
PHST- 2015/07/16 06:00 [medline]
PHST- 2020/01/07 00:00 [pmc-release]
AID - nrurol.2014.244 [pii]
AID - 10.1038/nrurol.2014.244 [doi]
PST - ppublish
SO  - Nat Rev Urol. 2014 Oct;11(10):579-88. doi: 10.1038/nrurol.2014.244. Epub 2014 Sep 
      16.