PMID- 25224628
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20220330
IS  - 1881-7823 (Electronic)
IS  - 1881-7815 (Linking)
VI  - 8
IP  - 4
DP  - 2014 Aug
TI  - Ferulic acid combined with astragaloside IV protects against vascular endothelial 
      dysfunction in diabetic rats.
PG  - 217-26
AB  - Dysfunction of the endothelium is regarded as an important factor in the 
      pathogenesis of vascular disease in diabetes mellitus (DM). Unfortunately, 
      prevention of the progression of vascular complications of DM remains 
      pessimistic. Ferulic acid and astragaloside IV, isolated from traditional Chinese 
      medicine Angelica sinensis and Radix astragali respectively, exhibit potential 
      cardio-protective and anti-hyperglycemic properties. In the present study, we 
      investigated the protective effects and underlying mechanism of ferulic acid and 
      astragaloside IV against vascular endothelial dysfunction in diabetic rats. After 
      the diabetic rat model was established using streptozotocin, sixty rats were 
      divided into 6 groups (control, model, ferulic acid, astragaloside IV, ferulic 
      acid + astragaloside IV, and metformin) and treated for 10 weeks. Blood samples 
      were collected to measure levels of hemoglobin A1c (HbAlc), triglyceride (TG), 
      total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), low density 
      lipoproteins (Ox-LDL), alanine aminotransferase (ALT), aspartate aminotransferase 
      (AST) and creatinine (Cr), nitric oxide (NO) and endothelial nitric oxide 
      synthase (eNOS), and abdominal aorta tissue samples were collected for observing 
      histological morphology changes of endothelium and detecting gene and protein 
      expression of nuclear factor-kappaB (NF-kappaB) P65, monocyte chemoattractant protein-1 
      (MCP-1), and tumor necrosis factor alpha (TNF-alpha). We found that ferulic acid combined 
      with astragaloside IV was capable of improving the structure of the aortic 
      endothelium wall, attenuating the increase of HbAlc, TG, TC, LDL-C and Ox-LDL, 
      promoting the release of NO and eNOS, and inhibiting over-activation of MCP-1, 
      TNF-alpha, and NF-kappaB P65, without damage to liver and kidney function. In conclusion, 
      ferulic acid combined with astragaloside IV exhibited significant protective 
      effects against vascular endothelial dysfunction in diabetic rats through the 
      NF-kappaB pathway involving decrease of Ox-LDL, increase of NO and eNOS, and 
      activation of NF-kappaB P65, MCP-1 and TNF-alpha.
FAU - Yin, Yonghui
AU  - Yin Y
AD  - Department of Endocrinology, the First Affiliated Hospital of Shandong University 
      of Traditional Chinese Medicine.
FAU - Qi, Fanghua
AU  - Qi F
FAU - Song, Zhenhua
AU  - Song Z
FAU - Zhang, Bo
AU  - Zhang B
FAU - Teng, Jialin
AU  - Teng J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biosci Trends
JT  - Bioscience trends
JID - 101502754
RN  - 0 (Coumaric Acids)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Saponins)
RN  - 0 (Triterpenes)
RN  - 3A592W8XKE (astragaloside A)
RN  - AVM951ZWST (ferulic acid)
SB  - IM
MH  - Animals
MH  - Aorta, Abdominal/drug effects/metabolism/pathology
MH  - Coumaric Acids/administration & dosage/chemistry/*therapeutic use
MH  - Diabetes Mellitus, Experimental/blood/complications/*drug therapy/metabolism
MH  - Diabetic Angiopathies/blood/etiology/metabolism/*prevention & control
MH  - Drug Therapy, Combination
MH  - Endothelium, Vascular/*drug effects/metabolism/pathology
MH  - Hypoglycemic Agents/administration & dosage/chemistry/*therapeutic use
MH  - Male
MH  - Molecular Structure
MH  - Rats, Wistar
MH  - Saponins/administration & dosage/chemistry/*therapeutic use
MH  - Triterpenes/administration & dosage/chemistry/*therapeutic use
EDAT- 2014/09/17 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/09/17 06:00
PHST- 2014/09/17 06:00 [entrez]
PHST- 2014/09/17 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - DN/JST.JSTAGE/bst/2014.01081 [pii]
AID - 10.5582/bst.2014.01081 [doi]
PST - ppublish
SO  - Biosci Trends. 2014 Aug;8(4):217-26. doi: 10.5582/bst.2014.01081.