PMID- 25224842
OWN - NLM
STAT- MEDLINE
DCOM- 20150619
LR  - 20151119
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 19
IP  - 7
DP  - 2014 Nov
TI  - Copeptin levels are independent of ingested nutrient type after standardised meal 
      administration--the CoMEAL study.
PG  - 557-62
LID - 10.3109/1354750X.2014.940504 [doi]
AB  - CONTEXT/OBJECTIVE: To clarify ambiguous published data, we determined whether 
      standardized nutrient intake influences serum copeptin concentrations. 
      MATERIALS/METHODS: Thirty healthy volunteers underwent oral glucose tolerance 
      testing (OGTT) and mixed-meal tolerance testing (MMTT), respectively drinking 
      300 ml/237 ml of glucose-containing or fat/protein/carbohydrate-containing fluid. 
      Copeptin was measured 30 min pre-("baseline")-180 min post-fluid intake. RESULTS: 
      Median [25th-75th percentile] copeptin fell from 4.9 [3.6-8.3]/4.9 [3.6-7.1] 
      pmol/l at OGTT/MMTT baselines to 3.2 (2.8-5.9)/4.1 (2.7-6.1) pmol/l at 
      post-OGTT/post-MMTT nadirs (150 min/120 min; p < 0.001, linear mixed-effect 
      modeling). DISCUSSION/CONCLUSIONS: Regardless of nutrient type ingested, copeptin 
      did not increase, suggesting values can be interpreted independently of prandial 
      status.
FAU - Walti, Carla
AU  - Walti C
AD  - Division of Endocrinology, Diabetology, and Metabolism, University Hospital , 
      Basel , Switzerland.
FAU - Siegenthaler, Judith
AU  - Siegenthaler J
FAU - Christ-Crain, Mirjam
AU  - Christ-Crain M
LA  - eng
SI  - ClinicalTrials.gov/NCT01772914
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20140916
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Biomarkers)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Proteins)
RN  - 0 (Glycopeptides)
RN  - 0 (copeptins)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Beverages
MH  - Biomarkers/blood
MH  - Dietary Carbohydrates/*administration & dosage/metabolism
MH  - Dietary Fats/*administration & dosage/metabolism
MH  - Dietary Proteins/*administration & dosage/metabolism
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycopeptides/*blood
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Nutritional Status
MH  - *Postprandial Period
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Time Factors
OTO - NOTNLM
OT  - AVP
OT  - fluid intake
OT  - food intake
OT  - glucose
OT  - prandial status
OT  - sodium
EDAT- 2014/09/17 06:00
MHDA- 2015/06/20 06:00
CRDT- 2014/09/17 06:00
PHST- 2014/09/17 06:00 [entrez]
PHST- 2014/09/17 06:00 [pubmed]
PHST- 2015/06/20 06:00 [medline]
AID - 10.3109/1354750X.2014.940504 [doi]
PST - ppublish
SO  - Biomarkers. 2014 Nov;19(7):557-62. doi: 10.3109/1354750X.2014.940504. Epub 2014 
      Sep 16.