PMID- 25226879
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2167-1044 (Print)
IS  - 2167-1044 (Electronic)
IS  - 2167-1044 (Linking)
VI  - 2013
IP  - S4
DP  - 2013 Oct 4
TI  - The Role of BDNF-TrkB Signaling in the Pathogenesis of PTSD.
LID - 006 [pii]
AB  - Posttraumatic Stress Disorder (PTSD) is a prevalent, chronic, and disabling 
      anxiety disorder that may develop following exposure to a traumatic event. The 
      majority of individuals with PTSD often have comorbid psychiatric conditions such 
      as major depression, generalized anxiety disorder, and substance use disorders, 
      and are at increased risk for suicide. Despite the public health significance of 
      PTSD, relatively little is known about the etiology or pathophysiology of this 
      disorder, and pharmacotherapy development to date has been largely opportunistic 
      instead of mechanism-based. One promising target for modulation is Tropomyosin 
      Receptor Kinase B (TrkB), the receptor for Brain-Derived Neurotrophic Factor 
      (BDNF), a signaling pathway important for neuronal plasticity, survival, and 
      growth. The following discusses how genetic and environmental alterations to this 
      signaling pathway may contribute to anatomical and functional changes in the 
      hippocampus, amygdala, anterior cingulate cortex, ventromedial prefrontal cortex, 
      and the nucleus accumbens. Changes in these brain regions may in turn contribute 
      to the predisposition to or maintenance of some of the clinical manifestations of 
      PTSD, including intrusive memories, hyperarousal, increased fear, and emotional 
      numbing.
FAU - Green, Christopher R
AU  - Green CR
AD  - Molecular Imaging Program, Department of Psychiatry and Radiology, New York 
      University School of Medicine, New York, USA.
FAU - Corsi-Travali, Stefani
AU  - Corsi-Travali S
AD  - Molecular Imaging Program, Department of Psychiatry and Radiology, New York 
      University School of Medicine, New York, USA.
FAU - Neumeister, Alexander
AU  - Neumeister A
AD  - Molecular Imaging Program, Department of Psychiatry and Radiology, New York 
      University School of Medicine, New York, USA ; Steven and Alexandra Cohen 
      Veterans Center for the Study of Posttraumatic Stress and Traumatic Brain Injury, 
      Department of Psychiatry, New York University Langone Medical Center, New York, 
      USA.
LA  - eng
GR  - R01 MH096876/MH/NIMH NIH HHS/United States
GR  - R21 MH085627/MH/NIMH NIH HHS/United States
GR  - R21 MH096105/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - J Depress Anxiety
JT  - Journal of depression & anxiety
JID - 101609478
PMC - PMC4161201
MID - NIHMS534080
OTO - NOTNLM
OT  - Bdnf-TrkB Signaling
OT  - Neurotrophic processes
OT  - Pathogenesis
OT  - Posttraumatic stress disorder
COIS- Conflict of Interest/Financial Disclosures The authors report no conflicts of 
      interest relevant to this article.
EDAT- 2014/09/18 06:00
MHDA- 2014/09/18 06:01
PMCR- 2014/09/11
CRDT- 2014/09/18 06:00
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2014/09/18 06:01 [medline]
PHST- 2014/09/11 00:00 [pmc-release]
AID - 006 [pii]
AID - 10.4172/2167-1044.S4-006 [doi]
PST - ppublish
SO  - J Depress Anxiety. 2013 Oct 4;2013(S4):006. doi: 10.4172/2167-1044.S4-006.