PMID- 25227285
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20211021
IS  - 1435-5604 (Electronic)
IS  - 0914-8779 (Linking)
VI  - 33
IP  - 5
DP  - 2015 Sep
TI  - Ultrasonographic evaluation of parathyroid hyperplasia in multiple endocrine 
      neoplasia type 1: Positive correlation between parathyroid volume and circulating 
      parathyroid hormone concentration.
PG  - 523-9
LID - 10.1007/s00774-014-0614-6 [doi]
AB  - There are few reports on parathyroid ultrasonography of multiple endocrine 
      neoplasia type 1 (MEN1). This study investigated the ultrasonographic features of 
      parathyroid glands in 10 patients with MEN1 who underwent preoperative neck 
      ultrasonography and parathyroidectomy between 2006 and 2010 at Toranomon 
      Hospital. We retrospectively analyzed clinical features, laboratory and 
      ultrasonographic data, and pathological diagnosis. A total of 38 parathyroid 
      glands were surgically removed (three to five glands from each patient). All 
      removed parathyroids were pathologically diagnosed as hyperplasia. Seven cases 
      (70.0 %) had adenomatous thyroid nodules. Twenty-five enlarged parathyroid glands 
      (65.8 %) were detected by preoperative ultrasonography with a detection rate of 
      81.8 % (9/11) and 59.3 % (16/27) for patients without and with adenomatous 
      nodules, respectively. Total parathyroid gland weight and potentially predictable 
      total parathyroid volume by preoperative ultrasonography were significantly 
      correlated with preoperative serum intact parathyroid hormone (iPTH) 
      concentration (R = 0.97, P < 0.001 and R = 0.96, P < 0.001, respectively). The 
      equation used for prediction of the total volume by ultrasonography was 15 x iPTH 
      (pg/ml) - 1,000 and that for total weight was 20 x iPTH (pg/ml) - 1,400. Although 
      adenomatous nodules often coexisted with MEN1 and made identification of enlarged 
      parathyroid glands by ultrasonography difficult, the positive correlation between 
      the predictable parathyroid volume by ultrasonography and serum iPTH suggests 
      that their measurement is useful in the preoperative detection and localization 
      of enlarged parathyroid glands in patients with MEN1. Furthermore, the presence 
      of parathyroid glands that should be resected can be predicted before surgery 
      using the equation proposed here.
FAU - Tamiya, Hiroyuki
AU  - Tamiya H
AD  - Division of Endocrinology, Toranomon Hospital Endocrine Center, 2-2-2 Toranomon 
      Minato-ku, 105-8470, Tokyo, Japan, tamiyatky@gmail.com.
FAU - Miyakawa, Megumi
AU  - Miyakawa M
FAU - Takeshita, Akira
AU  - Takeshita A
FAU - Miura, Daishu
AU  - Miura D
FAU - Takeuchi, Yasuhiro
AU  - Takeuchi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140917
PL  - Japan
TA  - J Bone Miner Metab
JT  - Journal of bone and mineral metabolism
JID - 9436705
RN  - 0 (Parathyroid Hormone)
RN  - 0 (Radiopharmaceuticals)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperplasia/*blood/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*blood/*diagnostic imaging/pathology
MH  - Parathyroid Glands/metabolism/*pathology
MH  - Parathyroid Hormone/*blood
MH  - Parathyroid Neoplasms/blood/pathology/ultrastructure
MH  - Parathyroidectomy/methods
MH  - Radiopharmaceuticals/administration & dosage
MH  - Retrospective Studies
MH  - Ultrasonography
EDAT- 2014/09/18 06:00
MHDA- 2016/06/09 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/04/10 00:00 [received]
PHST- 2014/06/26 00:00 [accepted]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 10.1007/s00774-014-0614-6 [doi]
PST - ppublish
SO  - J Bone Miner Metab. 2015 Sep;33(5):523-9. doi: 10.1007/s00774-014-0614-6. Epub 
      2014 Sep 17.