PMID- 25227454
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20161125
IS  - 1573-9686 (Electronic)
IS  - 0090-6964 (Linking)
VI  - 42
IP  - 12
DP  - 2014 Dec
TI  - Calculating intraventricular pressure difference using a multi-beat 
      spatiotemporal reconstruction of color m-mode echocardiography.
PG  - 2466-79
LID - 10.1007/s10439-014-1122-5 [doi]
AB  - This work aims to provide a methodology to improve the analysis of color-M-Mode 
      (CMM) echocardiograms, as used to assess cardiac function. Specifically, we 
      presented a methodology for the combined analysis of multiple heartbeat cycles 
      and improve the accuracy of intraventricular pressure difference (IVPD) 
      calculation. CMM sweep speed and heartbeat variations impact the accuracy of IVPD 
      calculation. Proper orthogonal decomposition (POD) is used to decompose and 
      reconstruct a representative CMM scan from multiple heartbeats, with reduced 
      noise and improved resolution. For three demonstration subjects, at least 9 beats 
      were recorded at sweep speeds of 25, 50, 75, 100, and 150 mm/s. For all subjects, 
      the beats from the 25 mm/s group resulted in low IVPD (median values: 1.93, 1.94 
      and 3.15 mmHg) compared to the 150 mm/s group (median values: 3.67, 3.98 and 
      5.18 mmHg). Reconstructed heartbeats for these subjects returned IVPD of 4.74, 
      3.23, and 5.14 mmHg. These results demonstrate the strong dependence of IVPD on 
      the temporal resolution and that the proposed reconstruction method can return 
      more accurate IVPDs for low resolution CMMs. This new method was applied to 5 
      clinical cohorts (3 normals, 1 restrictive, and 1 hypertrophied) and returned 
      increased median IVPD from 2.93-4.41 mmHg for Normal 1, 2.14-3.30 mmHg for Normal 
      2, 1.84-3.64 mmHg for Normal 3, 2.28-3.00 mmHg for restrictive and 1.56-1.69 mmHg 
      for hypertrophied. Our results show that beat-to-beat variations and temporal 
      resolution affect the IVPD. Our new method rectifies low resolutions and 
      beat-to-beat variability of the CMM data and allows for more accurate IVPD 
      measurement independent of scanner acquisition settings and beat variations.
FAU - Vlachos, Pavlos P
AU  - Vlachos PP
AD  - School of Mechanical Engineering, Purdue University, Purdue Mall, West Lafayette, 
      IN, 47906, USA, pvlachos@purdue.edu.
FAU - Niebel, Casandra L
AU  - Niebel CL
FAU - Chakraborty, Sreyashi
AU  - Chakraborty S
FAU - Pu, Min
AU  - Pu M
FAU - Little, William C
AU  - Little WC
LA  - eng
GR  - HL106276-01A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140917
PL  - United States
TA  - Ann Biomed Eng
JT  - Annals of biomedical engineering
JID - 0361512
SB  - IM
MH  - Adult
MH  - Aged
MH  - Echocardiography
MH  - Heart Diseases/*diagnostic imaging
MH  - Heart Rate
MH  - Humans
MH  - Middle Aged
MH  - Signal Processing, Computer-Assisted
MH  - *Ventricular Pressure
EDAT- 2014/09/18 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/09/18 06:00
PHST- 2013/11/02 00:00 [received]
PHST- 2014/09/11 00:00 [accepted]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1007/s10439-014-1122-5 [doi]
PST - ppublish
SO  - Ann Biomed Eng. 2014 Dec;42(12):2466-79. doi: 10.1007/s10439-014-1122-5. Epub 
      2014 Sep 17.