PMID- 25227841
OWN - NLM
STAT- MEDLINE
DCOM- 20150605
LR  - 20220408
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 15
IP  - 17
DP  - 2014
TI  - Elevated neutrophil-to-lymphocyte ratio in squamous cell carcinoma of larynx 
      compared to benign and precancerous laryngeal lesions.
PG  - 7351-5
AB  - BACKGROUND: Laryngeal carcinogenesis is a multifactorial process that has not 
      been fully elucidated. Despite extensive research, reliable markers with 
      diagnostic and prognostic value are still lacking. It was recently reported that 
      an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) may correlate with 
      an increased risk of recurrence, tumor aggressiveness and poorer prognosis in 
      various malignancies. The aim of this study was to examine whether NLR could be 
      used as an inflammatory marker to differentiate laryngeal squamous cell carcinoma 
      (LSCC) patients from benign laryngeal lesion (BLL) and precancerous laryngeal 
      lesion (PLL) patients. MATERIALS AND METHODS: This retrospective study was 
      performed on 209 patients admitted to a tertiary referral center with laryngeal 
      lesions and undergoing biopsies to establish their histopathological diagnosis. 
      We reviewed the patient files for their clinical, histopathological and 
      laboratory data. The patients were divided into three groups according to their 
      histopathological findings, as BLL, PLL and LSCC groups. The patients in the PLL 
      group were also divided into three subgroups as mild, moderate and severe 
      dysplasia/ carcinoma in situ (CIS) subgroups. The groups were compared for NLR 
      and the other laboratory data. RESULTS: The mean NLRs of the BLL, PLL and the 
      LSCC groups were 2.12 +/- 0.86, 2.32 +/- 0.68 and 3.46 +/- 1.51, respectively, and the 
      difference was statistically significant (p = 0.001). The mean NLRs of the 
      patients with PLL and LSCC were significantly higher than the patients with BLL 
      (p = 0.031 and p = 0.001, respectively). The mean NLRs were similar among mild 
      dysplasia, moderate dysplasia and severe dysplasia / CIS groups (p > 0.05). 
      CONCLUSIONS: To our knowledge, this is the first study investigating NLR in BLL, 
      PLL and LSCC. NLR is an inexpensive, reproducible and widely available blood 
      test, and could be a useful inflammatory marker to differentiate LSCC from BLL 
      and PLL.
FAU - Kum, Rauf Oguzhan
AU  - Kum RO
AD  - Ankara Numune Education and Research Hospital ENT Clinic, Ankara, Turkey E-mail : 
      adigerok@yahoo.com.tr.
FAU - Ozcan, Muge
AU  - Ozcan M
FAU - Baklaci, Deniz
AU  - Baklaci D
FAU - Kum, Nurcan Yurtsever
AU  - Kum NY
FAU - Yilmaz, Yavuz Fuat
AU  - Yilmaz YF
FAU - Gungor, Volkan
AU  - Gungor V
FAU - Unal, Adnan
AU  - Unal A
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma in Situ/*blood/diagnosis
MH  - Carcinoma, Squamous Cell/*blood/diagnosis
MH  - Female
MH  - Head and Neck Neoplasms/*blood/diagnosis
MH  - Humans
MH  - Laryngeal Diseases/blood/diagnosis
MH  - Laryngeal Neoplasms/*blood/diagnosis
MH  - Laryngitis/blood/diagnosis
MH  - Lymphocyte Count
MH  - Lymphocytes/*cytology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*blood
MH  - Neutrophils/*cytology
MH  - Polyps/blood/diagnosis
MH  - Precancerous Conditions/*blood/diagnosis
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2014/09/18 06:00
MHDA- 2015/06/06 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2015/06/06 06:00 [medline]
AID - 10.7314/apjcp.2014.15.17.7351 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2014;15(17):7351-5. doi: 10.7314/apjcp.2014.15.17.7351.