PMID- 25227868
OWN - NLM
STAT- MEDLINE
DCOM- 20150616
LR  - 20220330
IS  - 1572-8595 (Electronic)
IS  - 1383-875X (Linking)
VI  - 41
IP  - 2
DP  - 2014 Nov
TI  - Acute procedural and cryoballoon characteristics from cryoablation of atrial 
      fibrillation using the first- and second-generation cryoballoon: a retrospective 
      comparative study with follow-up outcomes.
PG  - 177-86
LID - 10.1007/s10840-014-9942-7 [doi]
AB  - PURPOSE: There is limited data available on the safety and efficacy of the 
      second-generation cryoballoon (CB-2) for cryoablation of atrial fibrillation 
      (Cryo-AF). We evaluated the procedural, biophysical, and clinical outcomes of 
      Cryo-AF in a large patient cohort using CB-2 as compared with the 
      first-generation cryoballoon (CB-1). METHODS: Three-hundred and forty consecutive 
      patients undergoing Cryo-AF with CB-1 (n = 140) and CB-2 (n = 200) were 
      retrospectively evaluated. RESULTS: Paroxysmal AF was more prevalent in CB-1 
      (86%) versus CB-2 (72%) (p = 0.001). During Cryo-AF, the mean balloon temperature 
      was lower with CB-2 at 30 s (8 versus -4 degrees C; p < 0.001) and 60 s (-26 versus 
      -32 degrees C; p < 0.001) with equivalent nadir temperatures (both at -50 degrees C; p = 0.542). 
      With CB-2, time-to-nadir temperature was shorter (232 versus 209 s; p < 0.001) 
      and thaw times were longer (47 versus 53 s; p < 0.001). Acute pulmonary vein (PV) 
      isolation rate was higher with CB-2 (92 versus 98%; p = 0.036) despite reduced 
      cryoablation time (61 versus 47 min; p < 0.001) and freeze area-under-the-curve 
      (-155,044 versus -116,740 s degrees C; p < 0.001). With CB-2, procedure time (209 versus 
      154 min; p < 0.001) and fluoroscopy time (42 versus 27 min; p < 0.001) were 
      shorter, with similar acute/long-term adverse events (AEs) and freedom from AF at 
      6, 9, and 12 months (89, 86, and 82%) during 16 +/- 8 months of follow-up. However, 
      CB-2 was associated with lower PV reconnection rates at redo ablation (30 versus 
      13%; p = 0.037). CONCLUSIONS: With CB-2, acute and long-term PV isolation rates 
      were higher despite shorter ablations, faster balloon cooling, and longer thaw 
      times, with similar AE rates and freedom from AF.
FAU - Aryana, Arash
AU  - Aryana A
AD  - Regional Cardiology Associates, 3941 J Street, Suite #350, Sacramento, CA, 95819, 
      USA, aaryana@rcamd.com.
FAU - Morkoch, Shemsa
AU  - Morkoch S
FAU - Bailey, Sean
AU  - Bailey S
FAU - Lim, Hae W
AU  - Lim HW
FAU - Sara, Rahmani
AU  - Sara R
FAU - d'Avila, Andre
AU  - d'Avila A
FAU - O'Neill, P Gearoid
AU  - O'Neill PG
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20140917
PL  - Netherlands
TA  - J Interv Card Electrophysiol
JT  - Journal of interventional cardiac electrophysiology : an international journal of 
      arrhythmias and pacing
JID - 9708966
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/diagnosis/mortality/*surgery
MH  - Catheter Ablation/*methods
MH  - Cohort Studies
MH  - Cryosurgery/instrumentation/*methods
MH  - Electrocardiography/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Patient Safety
MH  - Pulmonary Veins/*surgery
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Survival Rate
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2014/09/18 06:00
MHDA- 2015/06/17 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/04/05 00:00 [received]
PHST- 2014/07/29 00:00 [accepted]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2015/06/17 06:00 [medline]
AID - 10.1007/s10840-014-9942-7 [doi]
PST - ppublish
SO  - J Interv Card Electrophysiol. 2014 Nov;41(2):177-86. doi: 
      10.1007/s10840-014-9942-7. Epub 2014 Sep 17.