PMID- 25227934
OWN - NLM
STAT- MEDLINE
DCOM- 20160818
LR  - 20211021
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Print)
IS  - 1355-0284 (Linking)
VI  - 21
IP  - 6
DP  - 2015 Dec
TI  - Progressive multifocal leukoencephalopathy therapy.
PG  - 632-6
LID - 10.1007/s13365-014-0289-8 [doi]
AB  - Progressive multifocal leukoencephalopathy (PML) is caused by the JC virus in the 
      setting of chronic immune deficiency. Developing therapy has been challenged by 
      the rarity of the disease as well as the complexity of patients in whom it 
      develops. Several small trials directed at presumptive antiviral therapies have 
      failed to show convincing clinical efficacy. However, the prognosis of PML has 
      evolved from an almost uniformly fatal encephalitis to a disease where a majority 
      of patients survive. This improvement in outlook has been driven by effective 
      immune reconstitution strategies for the underlying disease, most prominently the 
      improved therapy for human immunodeficiency virus and ability to reverse the 
      effects of natalizumab. While a rapid acting and effective antiviral therapy 
      remains a sought for goal, optimal immune reconstitution to control JC virus 
      without causing brain-damaging immune reconstitution inflammatory syndrome (IRIS) 
      currently is the most practical approach to treat PML.
FAU - Clifford, David B
AU  - Clifford DB
AD  - Washington University School of Medicine, Box 8111, 660 South Euclid Avenue, 
      Saint Louis, MO, 63110, USA. cliffordd@neuro.wustl.edu.
LA  - eng
GR  - M01 RR000036/RR/NCRR NIH HHS/United States
GR  - UM1 AI069439/AI/NIAID NIH HHS/United States
GR  - UM1 AI069495/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140917
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
SB  - IM
MH  - Humans
MH  - JC Virus
MH  - Leukoencephalopathy, Progressive Multifocal/*therapy/virology
PMC - PMC4363307
MID - NIHMS629040
OTO - NOTNLM
OT  - IRIS
OT  - Immune reconstitution inflammatory syndrome
OT  - JC virus
OT  - Natalizumab
OT  - PML
OT  - Progressive multifocal leukoencephalopathy
EDAT- 2014/09/18 06:00
MHDA- 2016/08/19 06:00
PMCR- 2016/12/01
CRDT- 2014/09/18 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2014/09/05 00:00 [accepted]
PHST- 2014/09/03 00:00 [revised]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2016/08/19 06:00 [medline]
PHST- 2016/12/01 00:00 [pmc-release]
AID - 10.1007/s13365-014-0289-8 [pii]
AID - 10.1007/s13365-014-0289-8 [doi]
PST - ppublish
SO  - J Neurovirol. 2015 Dec;21(6):632-6. doi: 10.1007/s13365-014-0289-8. Epub 2014 Sep 
      17.