PMID- 2522809
OWN - NLM
STAT- MEDLINE
DCOM- 19890519
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 477
IP  - 1-2
DP  - 1989 Jan 16
TI  - D2 dopamine receptors in the rat prefrontal cortex: characterization and 
      alteration by stress.
PG  - 300-7
AB  - D2 dopamine (DA) receptors were characterized in the medial prefrontal cortex 
      (MPFC) of the rat by employing radioligand binding techniques which greatly 
      reduced [3H]spiperone binding to filters, S2 serotonin receptors and 
      spirodecanone sites. Competition studies suggested that the MPFC contains a 
      higher proportion of D2 [high] receptors than does the striatum. The IC50 values 
      of DA receptor antagonists in assays of MPFC tissue were correlated with their 
      antipsychotic potencies. Stress (footshock or tailshock) increased the density of 
      MPFC D2 dopamine receptors and decreased their affinity for [3H]spiperone. These 
      changes were delayed in onset, being present at 27 h but not at 3 h after 
      exposure to stress. The binding assay detected the changes when it was performed 
      at pH 7.9 but not when the pH was reduced to 6.2. D2 dopamine receptors in the 
      striatum and nucleus accumbens were not affected by stress.
FAU - MacLennan, A J
AU  - MacLennan AJ
AD  - Department of Psychiatry, University of British Columbia, Vancouver, Canada.
FAU - Pelleymounter, M A
AU  - Pelleymounter MA
FAU - Atmadja, S
AU  - Atmadja S
FAU - Jakubovic, A
AU  - Jakubovic A
FAU - Maier, S F
AU  - Maier SF
FAU - Fibiger, H C
AU  - Fibiger HC
LA  - eng
GR  - RSDA 00324/RS/DRS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Dopamine D2)
RN  - 4X6E73CJ0Q (Spiperone)
SB  - IM
MH  - Animals
MH  - Binding, Competitive
MH  - Cerebral Cortex/*metabolism
MH  - Kinetics
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/*metabolism
MH  - Receptors, Dopamine D2
MH  - Reference Values
MH  - Spiperone/metabolism
MH  - Stress, Psychological/*metabolism
EDAT- 1989/01/16 00:00
MHDA- 1989/01/16 00:01
CRDT- 1989/01/16 00:00
PHST- 1989/01/16 00:00 [pubmed]
PHST- 1989/01/16 00:01 [medline]
PHST- 1989/01/16 00:00 [entrez]
AID - 0006-8993(89)91418-2 [pii]
AID - 10.1016/0006-8993(89)91418-2 [doi]
PST - ppublish
SO  - Brain Res. 1989 Jan 16;477(1-2):300-7. doi: 10.1016/0006-8993(89)91418-2.