PMID- 25228460
OWN - NLM
STAT- MEDLINE
DCOM- 20150609
LR  - 20181202
IS  - 1423-0313 (Electronic)
IS  - 0031-7012 (Linking)
VI  - 94
IP  - 1-2
DP  - 2014
TI  - Drug fever due to a single dose of pantoprazole.
PG  - 78-9
LID - 10.1159/000364781 [doi]
AB  - Although proton pump inhibitors (PPI) are generally well tolerated, with most 
      adverse effects being minor and self-limiting, there are singular reports on 
      hypersensitivity immune reactions triggered by a PPI or its metabolites. Here we 
      report a case of acute drug-induced fever with leukocytosis and a transient 
      increase in CRP due to pantoprazole. This was apparently an idiosyncratic 
      reaction (inflammatory fever), showing no cross-sensitivity towards esomeprazole.
CI  - (c) 2014 S. Karger AG, Basel.
FAU - Schiller, Dietmar
AU  - Schiller D
AD  - Department of Internal Medicine IV, Elisabethinen Hospital, Linz, Austria.
FAU - Maieron, Andreas
AU  - Maieron A
FAU - Schofl, Rainer
AU  - Schofl R
FAU - Donnerer, Josef
AU  - Donnerer J
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140913
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - D8TST4O562 (Pantoprazole)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/administration & dosage/*adverse effects
MH  - Aged
MH  - Anti-Ulcer Agents/administration & dosage/adverse effects
MH  - Drug Hypersensitivity/*etiology
MH  - Esomeprazole/adverse effects/therapeutic use
MH  - Female
MH  - Fever/*chemically induced
MH  - Humans
MH  - Leukocytosis/chemically induced
MH  - Pantoprazole
MH  - Proton Pump Inhibitors/administration & dosage/*adverse effects
EDAT- 2014/09/18 06:00
MHDA- 2015/06/10 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/05/22 00:00 [received]
PHST- 2014/05/22 00:00 [accepted]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2015/06/10 06:00 [medline]
AID - 000364781 [pii]
AID - 10.1159/000364781 [doi]
PST - ppublish
SO  - Pharmacology. 2014;94(1-2):78-9. doi: 10.1159/000364781. Epub 2014 Sep 13.