PMID- 25228952
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140917
LR  - 20240508
IS  - 1949-8462 (Print)
IS  - 1949-8462 (Electronic)
VI  - 6
IP  - 8
DP  - 2014 Aug 26
TI  - Prehypertension: Underlying pathology and therapeutic options.
PG  - 728-43
LID - 10.4330/wjc.v6.i8.728 [doi]
AB  - Prehypertension (PHTN) is a global major health risk that subjects individuals to 
      double the risk of cardiovascular disease (CVD) independent of progression to 
      overt hypertension. Its prevalence rate varies considerably from country to 
      country ranging between 21.9% and 52%. Many hypotheses are proposed to explain 
      the underlying pathophysiology of PHTN. The most notable of these implicate the 
      renin-angiotensin system (RAS) and vascular endothelium. However, other processes 
      that involve reactive oxygen species, the inflammatory cytokines, prostglandins 
      and C-reactive protein as well as the autonomic and central nervous systems are 
      also suggested. Drugs affecting RAS have been shown to produce beneficial effects 
      in prehypertensives though such was not unequivocal. On the other hand, drugs 
      such as beta-adrenoceptor blocking agents were not shown to be useful. Leading 
      clinical guidelines suggest using dietary and lifestyle modifications as a first 
      line interventional strategy to curb the progress of PHTN; however, other 
      clinically respected views call for using drugs. This review provides an overview 
      of the potential pathophysiological processes associated with PHTN, abridges 
      current intervention strategies and suggests investigating the value of using the 
      "Polypill" in prehypertensive subjects to ascertain its potential in delaying (or 
      preventing) CVD associated with raised blood pressure in the presence of other 
      risk factors.
FAU - Albarwani, Sulayma
AU  - Albarwani S
AD  - Sulayma Albarwani, Sultan Al-Siyabi, Department of Physiology, College of 
      Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
FAU - Al-Siyabi, Sultan
AU  - Al-Siyabi S
AD  - Sulayma Albarwani, Sultan Al-Siyabi, Department of Physiology, College of 
      Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
FAU - Tanira, Musbah O
AU  - Tanira MO
AD  - Sulayma Albarwani, Sultan Al-Siyabi, Department of Physiology, College of 
      Medicine and Health Sciences, Sultan Qaboos University, Muscat 123, Oman.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Cardiol
JT  - World journal of cardiology
JID - 101537090
PMC - PMC4163702
OTO - NOTNLM
OT  - Polypill
OT  - Prehypertension
OT  - Renin-angiotensin system
OT  - Therapeutic lifestyle changes
EDAT- 2014/09/18 06:00
MHDA- 2014/09/18 06:01
PMCR- 2014/08/26
CRDT- 2014/09/18 06:00
PHST- 2013/12/17 00:00 [received]
PHST- 2014/06/08 00:00 [revised]
PHST- 2014/06/14 00:00 [accepted]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2014/09/18 06:01 [medline]
PHST- 2014/08/26 00:00 [pmc-release]
AID - 10.4330/wjc.v6.i8.728 [doi]
PST - ppublish
SO  - World J Cardiol. 2014 Aug 26;6(8):728-43. doi: 10.4330/wjc.v6.i8.728.