PMID- 25229850
OWN - NLM
STAT- MEDLINE
DCOM- 20150605
LR  - 20240109
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 78
IP  - 7
DP  - 2014
TI  - Anti-HIV-1 activity of phlorotannin derivative 8,4'''-dieckol from Korean brown 
      alga Ecklonia cava.
PG  - 1151-8
LID - 10.1080/09168451.2014.923282 [doi]
AB  - 8,4'''-dieckol is a natural product which has been isolated from brown alga, 
      Ecklonia cava. This polyphenolic compound is a phlorotannin derivative with a 
      broad range of bioactivities. Its inhibitory activity on human immunodeficiency 
      virus type-1 (HIV-1) was tested and the results indicated that 8,4'''-dieckol 
      inhibited HIV-1 induced syncytia formation, lytic effects, and viral p24 antigen 
      production at noncytotoxic concentrations. Furthermore, it was found that 
      8,4'''-dieckol selectively inhibited the activity of HIV-1 reverse trancriptase 
      (RT) enzyme with 91% inhibition ratio at the concentration of 50 muM. HIV-1 entry 
      was also inhibited by 8,4'''-dieckol. According to data from this study, 
      8,4'''-dieckol is an effective compound against HIV-1 with high potential for 
      further studies. These results suggest that it might be used as a drug candidate 
      for the development of new generation therapeutic agents, although further 
      studies on the mechanism of inhibition should be addressed.
FAU - Karadeniz, Fatih
AU  - Karadeniz F
AD  - a Marine Bioprocess Research Center , Pukyong National University , Busan , 
      Republic of Korea.
FAU - Kang, Kyong-Hwa
AU  - Kang KH
FAU - Park, Jae W
AU  - Park JW
FAU - Park, Sun-Joo
AU  - Park SJ
FAU - Kim, Se-Kwon
AU  - Kim SK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140612
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Benzofurans)
RN  - 0 (HIV Core Protein p24)
RN  - 0 (Tannins)
RN  - 0 (dieckol)
RN  - EC 2.7.7.- (reverse transcriptase, Human immunodeficiency virus 1)
RN  - EC 2.7.7.49 (HIV Reverse Transcriptase)
SB  - IM
MH  - Anti-HIV Agents/*chemistry/*pharmacology
MH  - Benzofurans/*chemistry/*pharmacology
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Cytopathogenic Effect, Viral/drug effects
MH  - Giant Cells/drug effects
MH  - HIV Core Protein p24/biosynthesis
MH  - HIV Reverse Transcriptase/antagonists & inhibitors
MH  - HIV-1/*drug effects/enzymology/metabolism/physiology
MH  - Humans
MH  - Phaeophyceae/*chemistry
MH  - T-Lymphocytes/cytology/drug effects
MH  - Tannins/*chemistry
MH  - Virus Internalization/drug effects
OTO - NOTNLM
OT  - 8,4'''-dieckol
OT  - Ecklonia cava
OT  - HIV-1 RT inhibition
OT  - phlorotannin
OT  - syncytia
EDAT- 2014/09/18 06:00
MHDA- 2015/06/06 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2015/06/06 06:00 [medline]
AID - 10.1080/09168451.2014.923282 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2014;78(7):1151-8. doi: 10.1080/09168451.2014.923282. 
      Epub 2014 Jun 12.