PMID- 25230058
OWN - NLM
STAT- MEDLINE
DCOM- 20160825
LR  - 20140918
IS  - 1847-6538 (Electronic)
IS  - 1330-027X (Linking)
VI  - 22
IP  - 3
DP  - 2014
TI  - Clinical features of the SAPHO syndrome and their role in choosing the 
      therapeutic approach: report of four patients and review of the literature.
PG  - 180-8
AB  - Although the SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome 
      was defined as a distinct entity more than 20 years ago, its classification 
      within the spectrum of inflammatory rheumatic diseases and the proper therapeutic 
      approach are still a matter of debate. We present four patients diagnosed with 
      the SAPHO syndrome treated and followed-up in our Department, demonstrating the 
      diversity of their clinical courses and their responses to different therapeutic 
      approaches. We also review the clinical, laboratory, and imaging features of the 
      SAPHO syndrome described in the relevant literature. Despite the growing quantity 
      of published data on the clinical features of the syndrome and the recognition of 
      two disease patterns (inflammatory and bone remodeling disease), it is still not 
      clear whether these possible disease subsets require different therapeutic 
      strategies. Tumor necrosis factor-alpha (TNF-alpha) inhibitors have been suggested to 
      be effective in patients with the inflammatory pattern, whereas bisphosphonates 
      seem to be effective in patients with bone remodeling disease; however, this is 
      still a hypothesis not yet confirmed by adequately designed clinical studies. 
      Further research is needed to assess disease features predicting favorable 
      response to the two therapeutic modalities beyond the first line of therapy - 
      TNF-alpha inhibitors and bisphosphonates.
FAU - Anic, Branimir
AU  - Anic B
FAU - Padjen, Ivan
AU  - Padjen I
AD  - Ivan Padjen, MD, Department of Internal Medicine, Division of Clinical Immunology 
      and Rheumatology, University of Zagreb School of Medicine, University Hospital 
      Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia; ivan_padjen@yahoo.ca.
FAU - Mayer, Miroslav
AU  - Mayer M
FAU - Bosnic, Dubravka
AU  - Bosnic D
FAU - Cerovec, Mislav
AU  - Cerovec M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - Croatia
TA  - Acta Dermatovenerol Croat
JT  - Acta dermatovenerologica Croatica : ADC
JID - 9433781
RN  - 0 (Diphosphonates)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acquired Hyperostosis Syndrome/diagnosis/*drug therapy
MH  - Adolescent
MH  - Adult
MH  - Comorbidity
MH  - Diphosphonates/*therapeutic use
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
EDAT- 2014/09/18 06:00
MHDA- 2016/08/26 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2016/08/26 06:00 [medline]
PST - ppublish
SO  - Acta Dermatovenerol Croat. 2014;22(3):180-8.