PMID- 25230227
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20191027
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 13
IP  - 7
DP  - 2014
TI  - Biological mechanisms linking Alzheimer's disease and type-2 diabetes mellitus.
PG  - 1192-201
AB  - The emerging data suggest that type 2 diabetes mellitus (T2DM) can contribute 
      significantly to the onset or progression of Alzheimer's disease (AD) either 
      directly or as a cofactor. Various in vitro and in vivo animal and human clinical 
      studies have provided evidence that T2DM is a major risk factor in the pathology 
      of AD and the two diseases share common biological mechanisms at the molecular 
      level. The biological mechanisms that are common in the pathology of both T2DM 
      and AD include insulin resistance, impaired glucose metabolism, beta-amyloid 
      formation, oxidative stress, and the presence of advanced glycation end products. 
      With better understanding of the degree of association between AD and T2DM and 
      the underlying molecular mechanisms explaining this relationship, it is hoped 
      that researchers will be able to develop effective therapeutic interventions to 
      treat or control T2DM and, as a consequence, delay the onset or progression of 
      AD.
FAU - Mushtaq, Gohar
AU  - Mushtaq G
FAU - Khan, Jalaluddin A
AU  - Khan JA
FAU - Kamal, Mohammad A
AU  - Kamal MA
AD  - Department of Biochemistry, College of Science, King Abdulaziz University, 
      Jeddah, Saudi Arabia. gmushtaq2001@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - 0 (Amyloid beta-Peptides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Alzheimer Disease/drug therapy/*physiopathology
MH  - Amyloid beta-Peptides/metabolism
MH  - Animals
MH  - Diabetes Mellitus, Type 2/drug therapy/*physiopathology
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Oxidative Stress
MH  - Risk Factors
EDAT- 2014/09/18 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/09/18 06:00
PHST- 2014/03/07 00:00 [received]
PHST- 2014/04/11 00:00 [revised]
PHST- 2014/04/12 00:00 [accepted]
PHST- 2014/09/18 06:00 [entrez]
PHST- 2014/09/18 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - CNSNDDT-EPUB-62380 [pii]
AID - 10.2174/1871527313666140917114537 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2014;13(7):1192-201. doi: 
      10.2174/1871527313666140917114537.