PMID- 25230956
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20150218
IS  - 1932-8494 (Electronic)
IS  - 1932-8486 (Linking)
VI  - 298
IP  - 3
DP  - 2015 Mar
TI  - Brain-derived neurotrofic factor and its receptor TrkB are present, but 
      segregated, within mature cutaneous Pacinian corpuscles of Macaca fascicularis.
PG  - 624-9
LID - 10.1002/ar.23050 [doi]
AB  - Some mechanoreceptors in mammals depend totally or in part on the neurotrophins 
      brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4), and their 
      receptor TrkB, for development and maintenance. These actions are presumably 
      exerced regulating the survival of discrete sensory neurons in the dorsal root 
      ganglia which form mechanoreceptors at the periphery. In addition, the cells 
      forming the mechanoreceptors also express both neurotrophins and their receptors 
      although large differences have been described among species. Pacinian corpuscles 
      are rapidly adapting low-threshold mechanoreceptors whose dependence from 
      neurotrophins is not known. In the present study, we analyzed expression of TrkB 
      and their ligands BDNF and NT-4 in the cutaneous Pacinian corpuscles of Macaca 
      fascicularis using immunohistochemistry and fluorescent microscopy. TrkB 
      immunoreactivity was found in Pacinian corpuscles where it co-localized with 
      neuron-specific enolase, and occasionally with S100 protein, thus suggesting that 
      TrkB expression is primarily into axons but also in the lamellar cells and even 
      in the outer core. On the other hand, BDNF immunoreactivity was found the inner 
      core cells where it co-localized with S100 protein but also in the innermost 
      layers of the outer core; NT-4 immunostaining was not detected. These results 
      describe for the first time the expression and distribution of a full 
      neurotrophin system in the axon-inner core complex of mature Pacinian corpuscles. 
      The data support previous findings demonstrating large differences in the 
      expression of BDNF-TrkB in mammalian mechanoreceptors, and also suggest the 
      existence of a retrograde trophic signaling mechanism to maintain morphological 
      and functional integrity of sensory neurons supplying Pacinian corpuscles.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Cabo, R
AU  - Cabo R
AD  - Departamento de Morfologia y Biologia Celular, Grupo SINPOS, Universidad de 
      Oviedo, Oviedo, Asturias, Spain.
FAU - Alonso, P
AU  - Alonso P
FAU - San Jose, I
AU  - San Jose I
FAU - Vazquez, G
AU  - Vazquez G
FAU - Pastor, J F
AU  - Pastor JF
FAU - Germana, A
AU  - Germana A
FAU - Vega, J A
AU  - Vega JA
FAU - Garcia-Suarez, O
AU  - Garcia-Suarez O
LA  - eng
PT  - Journal Article
DEP - 20140929
PL  - United States
TA  - Anat Rec (Hoboken)
JT  - Anatomical record (Hoboken, N.J. : 2007)
JID - 101292775
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Macaca fascicularis/*metabolism
MH  - Male
MH  - Pacinian Corpuscles/*metabolism
MH  - Receptor, trkB/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Macaca fascicularis
OT  - Pacinian corpuscles
OT  - TrkB
OT  - cutaneous mechanoreceptors
OT  - immunofluorescence
EDAT- 2014/09/19 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/09/19 06:00
PHST- 2014/01/23 00:00 [received]
PHST- 2014/04/23 00:00 [revised]
PHST- 2014/04/29 00:00 [accepted]
PHST- 2014/09/19 06:00 [entrez]
PHST- 2014/09/19 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1002/ar.23050 [doi]
PST - ppublish
SO  - Anat Rec (Hoboken). 2015 Mar;298(3):624-9. doi: 10.1002/ar.23050. Epub 2014 Sep 
      29.