PMID- 25231482
OWN - NLM
STAT- MEDLINE
DCOM- 20141222
LR  - 20211025
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 14
DP  - 2014 Sep 17
TI  - Acupuncture stimulation improves scopolamine-induced cognitive impairment via 
      activation of cholinergic system and regulation of BDNF and CREB expressions in 
      rats.
PG  - 338
LID - 10.1186/1472-6882-14-338 [doi]
LID - 338
AB  - BACKGROUND: Acupuncture is an alternative therapy that is widely used to treat 
      various neurodegenerative diseases and effectively improve cognitive and memory 
      impairment. The aim of this study was to examine whether acupuncture stimulation 
      at the Baihui (GV20) acupoint improves memory defects caused by scopolamine (SCO) 
      administration in rats. We also investigated the effects of acupuncture 
      stimulation at GV20 on the cholinergic system as well as the expression of 
      brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding 
      protein (CREB) in the hippocampus. METHODS: SCO (2 mg/kg, i.p.) was administered 
      to male rats once daily for 14 days. Acupuncture stimulation at GV20 was 
      performed for 5 min before SCO injection. After inducing cognitive impairment via 
      SCO administration, we conducted a passive avoidance test (PAT) and the Morris 
      water maze (MWM) test to assess behavior. RESULTS: Acupuncture stimulation at 
      GV20 improved memory impairment as measured by the PAT and reduced the escape 
      latency for finding the platform in the MWM test. Acupuncture stimulation at GV20 
      significantly alleviated memory-associated decreases in the levels of choline 
      acetyltransferase (ChAT), BDNF and CREB proteins in the hippocampus. 
      Additionally, acupuncture stimulation at GV20 significantly restored the 
      expression of choline transporter 1 (CHT1), vesicular acetylcholine transporter 
      (VAChT), BDNF and CREB mRNA in the hippocampus. These results demonstrate that 
      acupuncture stimulation at GV20 exerts significant neuroprotective effects 
      against SCO-induced neuronal impairment and memory dysfunction in rats. 
      CONCLUSIONS: These findings suggest that acupuncture stimulation at GV20 might be 
      useful in various neurodegenerative diseases to improve cognitive functioning via 
      stimulating cholinergic enzyme activities and regulating BDNF and CREB expression 
      in the brain.
FAU - Lee, Bombi
AU  - Lee B
AD  - Acupuncture and Meridian Science Research Center, College of Korean Medicine, 
      Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 130-701, Republic 
      of Korea. bombi@khu.ac.kr.
FAU - Sur, Bongjun
AU  - Sur B
FAU - Shim, Jaegul
AU  - Shim J
FAU - Hahm, Dae-Hyun
AU  - Hahm DH
FAU - Lee, Hyejung
AU  - Lee H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140917
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - DL48G20X8X (Scopolamine)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/analysis/*metabolism
MH  - Cognition Disorders/*chemically induced/*therapy
MH  - Cyclic AMP Response Element-Binding Protein/analysis/*metabolism
MH  - Hippocampus/chemistry
MH  - Male
MH  - Maze Learning/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Scopolamine/*adverse effects
PMC - PMC4180318
EDAT- 2014/09/19 06:00
MHDA- 2014/12/23 06:00
PMCR- 2014/09/17
CRDT- 2014/09/19 06:00
PHST- 2014/06/22 00:00 [received]
PHST- 2014/08/28 00:00 [accepted]
PHST- 2014/09/19 06:00 [entrez]
PHST- 2014/09/19 06:00 [pubmed]
PHST- 2014/12/23 06:00 [medline]
PHST- 2014/09/17 00:00 [pmc-release]
AID - 1472-6882-14-338 [pii]
AID - 1919 [pii]
AID - 10.1186/1472-6882-14-338 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2014 Sep 17;14:338. doi: 10.1186/1472-6882-14-338.