PMID- 25231834
OWN - NLM
STAT- MEDLINE
DCOM- 20151202
LR  - 20211021
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 265
IP  - 3
DP  - 2015 Apr
TI  - Focus on ECT seizure quality: serum BDNF as a peripheral biomarker in depressed 
      patients.
PG  - 227-32
LID - 10.1007/s00406-014-0543-3 [doi]
AB  - Electroconvulsive therapy (ECT) is a well-established, safe and effective 
      treatment in severest or drug-resistant affective disorders. The potential 
      relation between any peripheral biological marker and the seizure quality as a 
      surrogate for treatment efficacy has not been investigated so far. We 
      prospectively examined serum brain-derived neurotrophic factor (BDNF) levels in 
      20 patients with major depression before and after electroconvulsive therapy. A 
      seizure quality sum score for every ECT session was build up on the basis of the 
      seizure duration, seizure amplitude, central inhibition, interhemispheric 
      coherence and sympathetic activation. Serum BDNF levels were significantly higher 
      after ECT (P = 0.036). In the linear regression analysis, a significant 
      correlation of the serum BDNF levels and the time between the last ECT and the 
      blood withdrawal (P = 0.01) was observed. The ANOVA revealed a significant 
      influence of the interval between the last ECT and the blood withdrawal 
      (P = 0.0017) as well as the seizure quality (P = 0.038) on the variance of BDNF 
      serum levels. Our data corroborate the neurotrophin hypothesis suggesting an 
      ECT-induced central BDNF rise leading to a delayed (>6 days) and increased 
      equilibrium of the peripheral BDNF. The association of seizure adequacy with a 
      BDNF rise might underline the importance of monitoring seizure quality markers in 
      daily practice.
FAU - Bumb, Jan Malte
AU  - Bumb JM
AD  - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health 
      (CIMH), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
FAU - Aksay, Suna Su
AU  - Aksay SS
FAU - Janke, Christoph
AU  - Janke C
FAU - Kranaster, Laura
AU  - Kranaster L
FAU - Geisel, Olga
AU  - Geisel O
FAU - Gass, Peter
AU  - Gass P
FAU - Hellweg, Rainer
AU  - Hellweg R
FAU - Sartorius, Alexander
AU  - Sartorius A
LA  - eng
PT  - Journal Article
DEP - 20140918
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
CIN - Eur Arch Psychiatry Clin Neurosci. 2015 Jun;265(4):359-60. PMID: 25651974
CIN - Eur Arch Psychiatry Clin Neurosci. 2015 Jun;265(4):357-8. PMID: 25663302
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - Electroconvulsive Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Regression Analysis
MH  - Time Factors
EDAT- 2014/09/19 06:00
MHDA- 2015/12/15 06:00
CRDT- 2014/09/19 06:00
PHST- 2014/07/18 00:00 [received]
PHST- 2014/09/10 00:00 [accepted]
PHST- 2014/09/19 06:00 [entrez]
PHST- 2014/09/19 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.1007/s00406-014-0543-3 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2015 Apr;265(3):227-32. doi: 
      10.1007/s00406-014-0543-3. Epub 2014 Sep 18.