PMID- 25231846
OWN - NLM
STAT- MEDLINE
DCOM- 20150515
LR  - 20240229
IS  - 1689-0035 (Electronic)
IS  - 0065-1400 (Linking)
VI  - 74
IP  - 3
DP  - 2014
TI  - Effect of levetiracetam on penicillin induced epileptic activity in rats.
PG  - 266-75
LID - 1992 [pii]
LID - 10.55782/ane-2014-1992 [doi]
AB  - The aim of this study was to investigate the effects of levetiracetam (LEV) on 
      penicillin-induced epileptiform activity in rats. Penicillin was applied 
      intracerebroventricularly (icv) at a dose of 500 IU to induce epileptiform 
      activity. LEV was given intraperitoneally (ip) at doses of 20, 40, 80 mg/kg 
      before penicillin injection. This agent reduced epileptiform activity by 
      decreasing spike frequencies. The mean spike frequencies decreased significantly 
      in all the LEV treated groups. There was no significant change in the spike 
      amplitudes of the LEV groups compared with the control group. 40 mg/kg of LEV was 
      determined as the most effective dose on reducing epileptiform activity. The 
      results of this study suggest that LEV is an effective antiepileptic agent in 
      penicillin-induced epilepsy.
FAU - Arik, Aliye Erguvan
AU  - Arik AE
AD  - Hospital of Teaching and Research, Samsun, Turkey erguvan85@yahoo.com.
FAU - Bagirici, Faruk
AU  - Bagirici F
FAU - Sefil, Fatih
AU  - Sefil F
FAU - Marangoz, Cafer
AU  - Marangoz C
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Neurobiol Exp (Wars)
JT  - Acta neurobiologiae experimentalis
JID - 1246675
RN  - 0 (Anticonvulsants)
RN  - 0 (Penicillins)
RN  - 44YRR34555 (Levetiracetam)
RN  - ZH516LNZ10 (Piracetam)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Brain/*drug effects
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography/drug effects
MH  - Epilepsy/chemically induced/*drug therapy
MH  - Female
MH  - Levetiracetam
MH  - Penicillins/toxicity
MH  - Piracetam/administration & dosage/*analogs & derivatives/pharmacology
MH  - Rats, Wistar
EDAT- 2014/09/19 06:00
MHDA- 2015/05/16 06:00
CRDT- 2014/09/19 06:00
PHST- 2014/09/19 06:00 [entrez]
PHST- 2014/09/19 06:00 [pubmed]
PHST- 2015/05/16 06:00 [medline]
AID - 1992 [pii]
AID - 10.55782/ane-2014-1992 [doi]
PST - ppublish
SO  - Acta Neurobiol Exp (Wars). 2014;74(3):266-75. doi: 10.55782/ane-2014-1992.