PMID- 2523203
OWN - NLM
STAT- MEDLINE
DCOM- 19890512
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 256
IP  - 4 Pt 2
DP  - 1989 Apr
TI  - Dietary carbohydrates modify cardiac myosin isoenzyme profiles of semistarved 
      rats.
PG  - R976-81
AB  - Although food restriction reduces the relative expression of the rodent cardiac 
      myosin isoenzyme V1, the contribution of accompanying metabolic changes to the 
      induction and maintenance of this isoenzyme shift remains unknown. Hence, this 
      study was undertaken to determine the role of carbohydrate (CHO) utilization in 
      the regulation of cardiac myosin isoenzyme distribution in food-restricted rats. 
      Female Sprague-Dawley rats received either a mixed diet (55% of calories as CHO, 
      M) or a high-carbohydrate diet (75% of calories as CHO, HC). Additional animals 
      in each dietary group received daily injections of triiodothyronine (T3; 0.075 
      microgram/100 microM + T3, HC + T3). Three weeks of food restriction reduced left 
      ventricular Ca2+-activated myofibrillar adenosinetriphosphatase activity by 24% 
      and the relative amount of the myosin V1 isoenzyme by 57% in the M group relative 
      to free-eating controls (P less than 0.05). In contrast, these measures were 
      reduced by only 9 and 21%, respectively, in the HC group. Administration of T3 
      exerted no apparent effect on V1 expression, regardless of diet. Furthermore, the 
      increased expression of V1 in both HC and HC + T3 groups occurred independently 
      of changes in several measures of thyroid status including serum T3 levels, O2 
      consumption, heart rate, and systemic blood pressure. These results further 
      suggest that metabolic factors, specifically those associated with CHO 
      utilization, can influence cardiac myosin isoenzyme expression.
FAU - Morris, G S
AU  - Morris GS
AD  - Department of Physiology and Biophysics, University of California, Irvine 92717.
FAU - Herrick, R E
AU  - Herrick RE
FAU - Baldwin, K M
AU  - Baldwin KM
LA  - eng
GR  - 5 F32 AG05334/AG/NIA NIH HHS/United States
GR  - HL-38819/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Dietary Carbohydrates)
RN  - EC 3.6.4.1 (Myosins)
SB  - IM
MH  - Animals
MH  - Dietary Carbohydrates/*pharmacology
MH  - Female
MH  - Food Deprivation/*physiology
MH  - Myocardium/*enzymology
MH  - Myosins/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
OID - NASA: 89205818
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1152/ajpregu.1989.256.4.R976 [doi]
PST - ppublish
SO  - Am J Physiol. 1989 Apr;256(4 Pt 2):R976-81. doi: 10.1152/ajpregu.1989.256.4.R976.