PMID- 25232377
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140918
LR  - 20231104
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 7
IP  - 8
DP  - 2014
TI  - EGFR mutations in patients with non-small cell lung cancer from mainland China 
      and their relationships with clinicopathological features: a meta-analysis.
PG  - 1967-78
AB  - Many studies have reported the EGFR mutations in Chinese non small cell lung 
      cancer (NSCLC) patients and their relationship with clinicopathological 
      characteristics. But the frequency and type of EGFR mutations are varied. The 
      relationship between EGFR mutations and clinicopathological characteristics 
      remains unclear. We systematically reviewed studies of EGFR mutations in mainland 
      Chinese NSCLC patients. Standard statistical methods for meta-analysis were 
      applied. A total of 5,442 patients from 21 studies were included in the 
      meta-analysis. The overall EGFR mutation rate was 37.5% (2,039/5,442). Among 
      those 1,935 patients with detailed data about EGFR mutation types, the most 
      prevalent mutation type was L858R, which accounted for 38.3% of all EGFR 
      mutations. EGFR-TKIs sensitive mutations occupied 88.5% of all EGFR mutations. 
      While the acquired EGFR-TKIs resistant mutations (T790 M) could occur naturally 
      at the frequency of 1.5% without exposure of EGFR-TKIs. Male patients had a lower 
      mutation rate than female patients (32.6% versus 53.0%, OR=0.40, 95% CI: 
      0.34-0.48, P < 0.001). The EGFR mutation rate for smokers was 19.2%, lower than 
      that for non-smokers (47.9%) (OR = 0.40, 95% CI: 0.34-0.48, P < 0.001). Patients 
      with adenocarcinoma had a higher mutation rate than those with non-adenocarcinoma 
      (50.2% versus 17.0%, OR = 4.84, 95% CI: 4.07-5.75, P < 0.001). EGFR mutation rate 
      did not differ significantly between stage I and stage II/III/IV patients (35.8% 
      versus 32.2%, OR = 1.08, 95% CI: 0.84-1.43, P = 0.580). Our results show that 
      EGFR mutation rate is high in mainland Chinese NSCLC patients. EGFR-TKIs 
      sensitive mutations are main types of mutations. EGFR mutations are significantly 
      associated with gender, smoking history, histology type, but not stage.
FAU - Wang, Shuai
AU  - Wang S
AD  - Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, Shandong, P. R. China.
FAU - Wang, Zhou
AU  - Wang Z
AD  - Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong 
      University Jinan 250021, Shandong, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20140815
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4161537
OTO - NOTNLM
OT  - EGFR
OT  - Non-small cell lung cancer
OT  - clinicopathological features
OT  - mainland China
OT  - mutation analysis
OT  - targeted therapy
EDAT- 2014/09/19 06:00
MHDA- 2014/09/19 06:01
PMCR- 2014/08/15
CRDT- 2014/09/19 06:00
PHST- 2014/05/30 00:00 [received]
PHST- 2014/06/14 00:00 [accepted]
PHST- 2014/09/19 06:00 [entrez]
PHST- 2014/09/19 06:00 [pubmed]
PHST- 2014/09/19 06:01 [medline]
PHST- 2014/08/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2014 Aug 15;7(8):1967-78. eCollection 2014.